PMID- 27092594
OWN - NLM
STAT- MEDLINE
DCOM- 20170518
LR  - 20181113
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 79
IP  - 11
DP  - 2016
TI  - Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat 
      behavior and cognition.
PG  - 447-52
LID - 10.1080/15287394.2016.1164101 [doi]
AB  - It is generally accepted that gestational xenobiotic exposures result in systemic 
      consequences in the adult F1 generation. However, data on detailed behavioral and 
      cognitive consequences remain limited. Using our whole-body nanoparticle 
      inhalation facility, pregnant Sprague-Dawley rats (gestational day [GD] 7) were 
      exposed 4 d/wk to either filtered air (control) or nano-titanium dioxide aerosols 
      (nano-TiO2; count median aerodynamic diameter of 170.9 +/- 6.4 nm, 10.4 +/- 0.4 
      mg/m(3), 5 h/d) for 7.8 +/- 0.5 d of the remaining gestational period. All rats 
      received their final exposure on GD 20 prior to delivery. The calculated daily 
      maternal deposition was 13.9 +/- 0.5 microg. Subsequently, at 5 mo of age, behavior and 
      cognitive functions of these pups were evaluated employing a standard battery of 
      locomotion, learning, and anxiety tests. These assessments revealed significant 
      working impairments, especially under maximal mnemonic challenge, and possible 
      deficits in initial motivation in male F1 adults. Evidence indicates that 
      maternal engineered nanomaterial exposure during gestation produces psychological 
      deficits that persist into adulthood in male rats.
FAU - Engler-Chiurazzi, Elizabeth B
AU  - Engler-Chiurazzi EB
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - b Center for Basic and Translational Stroke Research, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Stapleton, Phoebe A
AU  - Stapleton PA
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - c Center for Cardiovascular and Respiratory Sciences, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Stalnaker, Jessica J
AU  - Stalnaker JJ
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - b Center for Basic and Translational Stroke Research, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Ren, Xuefang
AU  - Ren X
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - b Center for Basic and Translational Stroke Research, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Hu, Heng
AU  - Hu H
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - b Center for Basic and Translational Stroke Research, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Nurkiewicz, Timothy R
AU  - Nurkiewicz TR
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - c Center for Cardiovascular and Respiratory Sciences, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - McBride, Carroll R
AU  - McBride CR
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - c Center for Cardiovascular and Respiratory Sciences, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Yi, Jinghai
AU  - Yi J
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - c Center for Cardiovascular and Respiratory Sciences, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Engels, Kevin
AU  - Engels K
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - c Center for Cardiovascular and Respiratory Sciences, West Virginia University , 
      Morgantown , West Virginia , USA.
FAU - Simpkins, James W
AU  - Simpkins JW
AD  - a Department of Physiology and Pharmacology , West Virginia University , 
      Morgantown , West Virginia , USA.
AD  - b Center for Basic and Translational Stroke Research, West Virginia University , 
      Morgantown , West Virginia , USA.
LA  - eng
GR  - K99 ES024783/ES/NIEHS NIH HHS/United States
GR  - P20 GM109098/GM/NIGMS NIH HHS/United States
GR  - P01 AG022550/AG/NIA NIH HHS/United States
GR  - P01 AG027956/AG/NIA NIH HHS/United States
GR  - U54 GM104942/GM/NIGMS NIH HHS/United States
GR  - F32 ES023435/ES/NIEHS NIH HHS/United States
GR  - R01 ES015022/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160419
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - Cognition/*drug effects
MH  - Female
MH  - Male
MH  - Maternal Exposure
MH  - Metal Nanoparticles/*toxicity
MH  - Motor Activity/*drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Titanium/*toxicity
PMC - PMC4899177
MID - NIHMS783351
EDAT- 2016/04/20 06:00
MHDA- 2017/05/19 06:00
PMCR- 2017/04/19
CRDT- 2016/04/20 06:00
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2017/05/19 06:00 [medline]
PHST- 2017/04/19 00:00 [pmc-release]
AID - 10.1080/15287394.2016.1164101 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2016;79(11):447-52. doi: 
      10.1080/15287394.2016.1164101. Epub 2016 Apr 19.