PMID- 27097787
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20170523
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 12
IP  - 9
DP  - 2016 Sep
TI  - The role of proton pump inhibitor therapy in the management of eosinophilic 
      esophagitis.
PG  - 945-52
LID - 10.1080/1744666X.2016.1178574 [doi]
AB  - Eosinophilic esophagitis (EoE) is a chronic esophageal disease characterized by a 
      Th2 inflammatory response triggered by food/environmental allergens. Solid data 
      confirm that up to half of patients with suspected EoE achieve complete remission 
      on proton pump inhibitors (PPI) therapy. This disease phenotype is currently 
      labelled as PPI-responsive esophageal eosinophilia (PPI-REE). Albeit initially 
      believed to represent gastro-esophageal reflux disease (GERD), evolving evidence 
      has underscored that PPI-REE and EoE show a significant overlap regarding clinic, 
      endoscopic, histologic, Th2 immune-mediated inflammation and gene expression 
      features. Moreover, PPI therapy can effectively reverse Th2 inflammation and the 
      EoE transcriptome expression in PPI-REE patients. Therefore, EoE and PPI-REE 
      likely represent a common allergic disorder, where PPI therapy should be 
      considered a short- and long-term therapeutic asset, along with diet and topical 
      steroids.
FAU - Molina-Infante, Javier
AU  - Molina-Infante J
AD  - a Department of Gastroenterology , Hospital San Pedro de Alcantara , Caceres , 
      Spain.
FAU - Prados-Manzano, Raul
AU  - Prados-Manzano R
AD  - a Department of Gastroenterology , Hospital San Pedro de Alcantara , Caceres , 
      Spain.
FAU - Gonzalez-Cordero, Pedro Luis
AU  - Gonzalez-Cordero PL
AD  - a Department of Gastroenterology , Hospital San Pedro de Alcantara , Caceres , 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160428
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Animals
MH  - Eosinophilia/*drug therapy
MH  - Eosinophilic Esophagitis/*drug therapy
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Inflammation
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Th2 Cells/*drug effects/immunology
MH  - Transcriptome/drug effects
OTO - NOTNLM
OT  - Eosinophilic esophagitis
OT  - gastro-esophageal reflux disease
OT  - proton pump inhibitor drugs
OT  - proton pump inhibitor responsive esophageal eosinophilia
EDAT- 2016/04/22 06:00
MHDA- 2017/05/24 06:00
CRDT- 2016/04/22 06:00
PHST- 2016/04/22 06:00 [entrez]
PHST- 2016/04/22 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
AID - 10.1080/1744666X.2016.1178574 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2016 Sep;12(9):945-52. doi: 
      10.1080/1744666X.2016.1178574. Epub 2016 Apr 28.