PMID- 27097809
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20181113
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 469
IP  - 1
DP  - 2016 Jul
TI  - In a cohort of breast cancer screened patients the proportion of HER2 positive 
      cases is lower than that earlier reported and pathological characteristics differ 
      between HER2 3+ and HER2 2+/Her2 amplified cases.
PG  - 45-50
LID - 10.1007/s00428-016-1940-y [doi]
AB  - Human epithelial growth factor receptor 2 (HER2) overexpression and/or 
      amplification is of predictive and prognostic value in infiltrating breast 
      carcinoma (IBC). We evaluated the proportion of HER2-positive cases (score 3 
      overexpression/score 2 plus fluorescence in situ hybridization (FISH) 
      amplification) in a consecutive series of 2163 patients. According to 
      immunohistochemical analysis of HER2 expression, using Herceptest and FDA 
      criteria, 839 cases had score 0, 476 score 1+, 699 score 2+, and 149 score 3+. Of 
      the 699 scoring 2+ cases, 160 (22.88 %) showed Her2 gene amplification by FISH 
      analysis, making a total of 309 (14.28 %) HER2-positive cases. Grade 1 ductal and 
      special type IBC were never HER2 positive, while only three infiltrating lobular 
      carcinomas but a relevant percentage of small IBC were HER2 positive. Of 
      HER2-positive cases, 52.1 % was pT1 and of these, 38.5 % was pT1b or smaller. 
      Logistic regression analysis revealed that estrogen receptor (ER), progesterone 
      receptor (PgR), grade, and pT were significantly associated with HER2 positivity 
      and that HER2 3+ cases were more frequently of higher grade and pT than HER2 
      2+/Her2 amplified cases. In addition, HER2 3+ cases were more frequently in ER 
      and PgR negative than HER2 2+/Her2 amplified cases. We conclude that the 
      proportion of HER2 positive cases is lower than that reported in older literature 
      and that pathological characteristics differ between HER2 3+ and HER2 2+/Her2 
      amplified cases.
FAU - Giuliani, Silvia
AU  - Giuliani S
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy.
FAU - Ciniselli, Chiara Maura
AU  - Ciniselli CM
AD  - Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS 
      Istituto Nazionale dei Tumori, Milan, Italy.
FAU - Leonardi, Elena
AU  - Leonardi E
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy.
FAU - Polla, Enzo
AU  - Polla E
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy.
FAU - Decarli, Nicola
AU  - Decarli N
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy.
FAU - Luchini, Claudio
AU  - Luchini C
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy.
FAU - Cantaloni, Chiara
AU  - Cantaloni C
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy.
FAU - Gasperetti, Fabio
AU  - Gasperetti F
AD  - 1st Unit of Surgery, Santa Chiara Hospital, Trento, Italy.
FAU - Cazzolli, Daniela
AU  - Cazzolli D
AD  - 1st Unit of Surgery, Santa Chiara Hospital, Trento, Italy.
FAU - Berlanda, Gabriella
AU  - Berlanda G
AD  - 2nd Unit of Surgery, Santa Chiara Hospital, Trento, Italy.
FAU - Bernardi, Daniela
AU  - Bernardi D
AD  - Unit of Senology, Azienda Provinciale Servizi Sanitari, Trento, Italy.
FAU - Pellegrini, Marco
AU  - Pellegrini M
AD  - Unit of Senology, Azienda Provinciale Servizi Sanitari, Trento, Italy.
FAU - Triolo, Renza
AU  - Triolo R
AD  - Unit of Medical Oncology, Santa Chiara Hospital, Trento, Italy.
FAU - Ferro, Antonella
AU  - Ferro A
AD  - Unit of Medical Oncology, Santa Chiara Hospital, Trento, Italy.
FAU - Verderio, Paolo
AU  - Verderio P
AD  - Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS 
      Istituto Nazionale dei Tumori, Milan, Italy.
FAU - Barbareschi, Mattia
AU  - Barbareschi M
AD  - Unit of Surgical Pathology, Santa Chiara Hospital, Largo Medaglie Oro 9, 38122, 
      Trento, Italy. mattia.barbareschi@apss.tn.it.
AD  - Trentino Biobank, Unit of Surgical Pathology, Santa Chiara Hospital, Trento, 
      Italy. mattia.barbareschi@apss.tn.it.
LA  - eng
PT  - Journal Article
DEP - 20160421
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/*diagnosis/metabolism/pathology
MH  - Carcinoma, Lobular/diagnosis/metabolism/pathology
MH  - Early Detection of Cancer/methods
MH  - Female
MH  - Gene Amplification/genetics
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Middle Aged
MH  - *Predictive Value of Tests
MH  - Prognosis
MH  - Receptor, ErbB-2/*metabolism
MH  - Receptors, Estrogen/*metabolism
MH  - Receptors, Progesterone/metabolism
OTO - NOTNLM
OT  - Breast carcinoma
OT  - FISH
OT  - HER2
OT  - Immunohistochemistry
EDAT- 2016/04/22 06:00
MHDA- 2017/02/18 06:00
CRDT- 2016/04/22 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2016/04/04 00:00 [accepted]
PHST- 2015/12/08 00:00 [revised]
PHST- 2016/04/22 06:00 [entrez]
PHST- 2016/04/22 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
AID - 10.1007/s00428-016-1940-y [pii]
AID - 10.1007/s00428-016-1940-y [doi]
PST - ppublish
SO  - Virchows Arch. 2016 Jul;469(1):45-50. doi: 10.1007/s00428-016-1940-y. Epub 2016 
      Apr 21.