PMID- 27098790
OWN - NLM
STAT- MEDLINE
DCOM- 20170307
LR  - 20220318
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 129
IP  - 9
DP  - 2016 May 5
TI  - Association Analysis of Proteasome Subunits and Transporter Associated with 
      Antigen Processing on Chinese Patients with Parkinson's Disease.
PG  - 1053-8
LID - 10.4103/0366-6999.180513 [doi]
AB  - BACKGROUND: Proteasome subunits (PSMB) and transporter associated with antigen 
      processing (TAP) loci are located in the human leukocyte antigen (HLA) Class II 
      region play important roles in immune response and protein degradation in 
      neurodegenerative diseases. This study aimed to explore the association between 
      single nucleotide polymorphisms (SNPs) of PSMB and TAP and Parkinson's disease 
      (PD). METHODS: A case-control study was conducted by genotyping SNPs in PSMB8, 
      PSMB9, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 
      sporadic patients with PD and 674 healthy controls. Nine identified SNPs in 
      PSMB8, PSMB9, TAP1, and TAP2 were genotyped through SNaPshot testing. RESULTS: 
      The stratified analysis of rs17587 was specially performed on gender. Data 
      revealed that female patients carry a higher frequency of rs17587-G/G versus (A/A 
      + G/A) compared with controls. But there was no significant difference with 
      respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in 
      PD patients. CONCLUSION: Chinese females carrying the rs17587-G/G genotype in 
      PSMB9 may increase a higher risk for PD, but no linkage was found between other 
      SNPs in HLA Class II region and PD.
FAU - Mo, Ming-Shu
AU  - Mo MS
FAU - Huang, Wei
AU  - Huang W
FAU - Sun, Cong-Cong
AU  - Sun CC
FAU - Zhang, Li-Min
AU  - Zhang LM
FAU - Cen, Luan
AU  - Cen L
FAU - Xiao, You-Sheng
AU  - Xiao YS
FAU - Li, Guo-Fei
AU  - Li GF
FAU - Yang, Xin-Ling
AU  - Yang XL
FAU - Qu, Shao-Gang
AU  - Qu SG
FAU - Xu, Ping-Yi
AU  - Xu PY
AD  - Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, Guangdong 510080; Department of Neurology, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (TAP1 protein, human)
RN  - 144416-78-4 (LMP-2 protein)
RN  - 145892-13-3 (TAP2 protein, human)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (LMP7 protein)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2/*genetics
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3/*genetics
MH  - Adult
MH  - Aged
MH  - *Antigen Presentation
MH  - Case-Control Studies
MH  - Cysteine Endopeptidases/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*genetics/immunology
MH  - *Polymorphism, Single Nucleotide
MH  - Proteasome Endopeptidase Complex/*genetics
PMC - PMC4852672
EDAT- 2016/04/22 06:00
MHDA- 2017/03/08 06:00
PMCR- 2016/05/05
CRDT- 2016/04/22 06:00
PHST- 2016/04/22 06:00 [entrez]
PHST- 2016/04/22 06:00 [pubmed]
PHST- 2017/03/08 06:00 [medline]
PHST- 2016/05/05 00:00 [pmc-release]
AID - ChinMedJ_2016_129_9_1053_180513 [pii]
AID - CMJ-129-1053 [pii]
AID - 10.4103/0366-6999.180513 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2016 May 5;129(9):1053-8. doi: 10.4103/0366-6999.180513.