PMID- 27100527 OWN - NLM STAT- MEDLINE DCOM- 20170424 LR - 20181113 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 32 IP - 7 DP - 2016 Jul TI - Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. PG - 1093-101 LID - 10.1007/s10554-016-0878-0 [doi] AB - The aim of this study was to assess cardiac deformation patterns in myocarditis applying feature tracking imaging (FTI) to cardiovascular magnetic resonance (CMR) images. Thirty-six patients (31 males) with acute myocarditis and 36 age- and gender-matched healthy volunteers were studied. CMR examinations were performed in a 1.5 T MR-scanner including late gadolinium enhancement (LGE). FTI was applied to standard cine images of long and short axis views. Global peak circumferential, longitudinal and radial systolic strains as well as long axis strain (LAS) were measured. Patients showed significantly impaired global peak circumferential (-24.4 +/- 4.2 % vs. -28.8 +/- 3.8 %, p < 0.0001), longitudinal (-17.6 +/- 4.4 % vs. -23.8 +/- 3.1 %, p < 0.0001) and radial (26.1 +/- 5.4 % vs. 37.9 +/- 7.6 %, p < 0.0001) systolic strains. Even patients with a preserved ejection fraction (pEF, >/=55 %) had significantly reduced longitudinal (-20.0 +/- 4.8 % vs. -23.8 +/- 3.1 %, p < 0.01) and radial (27.7 +/- 5.5 % vs. 37.9 +/- 7.6 %, p < 0.0001) strains. The extent of LGE in patients did not correlate to their respective strains. Regarding the differentiation between patients and controls, the addition of global peak systolic strains to ejection fraction led to a significant improvement of the logistic regression model (chi(2) 48.7 vs. 71.5; p < 0.001) resulting in a high AUC of 0.98. Applying previously published reference values, 75 % or 31 % of patients with pEF showed at least one strain value or a LAS, which fell below the limit of 1 or respectively 2 standard deviations from the reference mean value. Cardiac strains measured by CMR-FTI are significantly impaired in patients with acute myocarditis even in those with pEF. Therefore, strain assessment may improve the diagnostic accuracy of CMR for myocarditis. FAU - Andre, Florian AU - Andre F AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. FAU - Stock, Florian T AU - Stock FT AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. FAU - Riffel, Johannes AU - Riffel J AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. FAU - Giannitsis, Evangelos AU - Giannitsis E AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. FAU - Steen, Henning AU - Steen H AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. FAU - Scharhag, Jurgen AU - Scharhag J AD - Institute for Sports and Preventive Medicine, Saarland University, Campus Geb. B8 2, 66123, Saarbrucken, Germany. FAU - Katus, Hugo A AU - Katus HA AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. FAU - Buss, Sebastian J AU - Buss SJ AD - Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. sebastian.buss@med.uni-heidelberg.de. LA - eng PT - Journal Article DEP - 20160421 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Acute Disease MH - Adult MH - Analysis of Variance MH - Area Under Curve MH - Chi-Square Distribution MH - Contrast Media/administration & dosage MH - Female MH - Gadolinium DTPA/administration & dosage MH - Humans MH - Image Interpretation, Computer-Assisted MH - Logistic Models MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - *Myocardial Contraction MH - Myocarditis/*diagnostic imaging/physiopathology MH - Predictive Value of Tests MH - ROC Curve MH - Retrospective Studies MH - Stress, Mechanical MH - Stroke Volume MH - Ventricular Function, Left OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Feature tracking OT - Myocarditis OT - Strain EDAT- 2016/04/22 06:00 MHDA- 2017/04/25 06:00 CRDT- 2016/04/22 06:00 PHST- 2015/12/06 00:00 [received] PHST- 2016/03/15 00:00 [accepted] PHST- 2016/04/22 06:00 [entrez] PHST- 2016/04/22 06:00 [pubmed] PHST- 2017/04/25 06:00 [medline] AID - 10.1007/s10554-016-0878-0 [pii] AID - 10.1007/s10554-016-0878-0 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2016 Jul;32(7):1093-101. doi: 10.1007/s10554-016-0878-0. Epub 2016 Apr 21.