PMID- 27101759
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20170110
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 36
IP  - 5
DP  - 2016 May
TI  - Conjugated linoleic acid mitigates testosterone-related changes in body 
      composition in male guinea pigs.
PG  - 408-17
LID - S0271-5317(15)00320-6 [pii]
LID - 10.1016/j.nutres.2015.12.013 [doi]
AB  - We hypothesize that conjugated linoleic acid (CLA) may be effective in preventing 
      the changes in total and regional body composition and increases in interleukin 
      (IL) 6 that occur as a result of hypogonadism. Male guinea pigs (n = 40, 70- to 
      72-week retired breeders) were block randomized by weight into 4 groups: (1) sham 
      surgery (SHAM)/control (CTRL) diet, (2) SHAM/conjugated linoleic acid (CLA) diet 
      (1%), (3) orchidectomy (ORX)/CTRL diet, and (4) ORX/CLA diet. Dual-energy x-ray 
      absorptiometry scans were performed at baseline and week 16 to assess body 
      composition. Serum IL-6 was analyzed using an enzyme-linked immune sorbent assay. 
      Fatty acids (FAs) from visceral and subcutaneous adipose tissue were analyzed 
      using gas chromatography. In ORX/CTRL guinea pigs, percent total body fat 
      increased by 6.1%, and percent lean mass decreased by 6.7% over the 16-week 
      treatment period, whereas no changes were observed for either parameter in 
      ORX/CLA guinea pigs. Guinea pigs fed the CLA diet gained less percent total, 
      upper, and lower body fat than those fed the CTRL diet regardless of surgical 
      treatment. Regional adipose tissue FA composition was reflective of dietary FAs. 
      Serum IL-6 concentrations were not different among groups. In this study, we 
      observed that, in male guinea pigs, hypogonadism resulted in increased fat mass 
      and decreased lean mass. In addition, CLA was effective in reducing gains in body 
      fat and maintaining lean mass in both hypogonadal and intact guinea pigs.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Yang, Susan Q
AU  - Yang SQ
AD  - School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, 
      Canada.
FAU - DeGuire, Jason R
AU  - DeGuire JR
AD  - School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, 
      Canada.
FAU - Lavery, Paula
AU  - Lavery P
AD  - School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, 
      Canada.
FAU - Mak, Ivy L
AU  - Mak IL
AD  - School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, 
      Canada.
FAU - Weiler, Hope A
AU  - Weiler HA
AD  - School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, 
      Canada.
FAU - Santosa, Sylvia
AU  - Santosa S
AD  - Department of Exercise Science, Concordia University, Montreal, QC H4B 1R6, 
      Canada; Nutrition, Obesity and Metabolism Lab, PERFORM Centre, Concordia 
      University, Montreal, QC H4B 1R6, Canada. Electronic address: 
      s.santosa@concordia.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160106
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Fatty Acids)
RN  - 0 (Interleukin-6)
RN  - 0 (Linoleic Acids, Conjugated)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adipose Tissue/chemistry
MH  - Animals
MH  - Body Composition/*drug effects/*physiology
MH  - Fatty Acids/analysis
MH  - Guinea Pigs
MH  - Hypogonadism
MH  - Interleukin-6/blood
MH  - Linoleic Acids, Conjugated/*administration & dosage
MH  - Male
MH  - Orchiectomy
MH  - Testosterone/blood/deficiency/*physiology
OTO - NOTNLM
OT  - Body fat
OT  - Conjugated linoleic acid
OT  - Guinea pig
OT  - Hypogonadal
OT  - Interleukin-6
OT  - Testosterone
EDAT- 2016/04/23 06:00
MHDA- 2017/01/10 06:00
CRDT- 2016/04/23 06:00
PHST- 2015/10/01 00:00 [received]
PHST- 2015/12/14 00:00 [revised]
PHST- 2015/12/23 00:00 [accepted]
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - S0271-5317(15)00320-6 [pii]
AID - 10.1016/j.nutres.2015.12.013 [doi]
PST - ppublish
SO  - Nutr Res. 2016 May;36(5):408-17. doi: 10.1016/j.nutres.2015.12.013. Epub 2016 Jan 
      6.