PMID- 27102898
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20181113
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 39
IP  - 3
DP  - 2016 Jun
TI  - Tormentic Acid Inhibits IL-1beta-Induced Inflammatory Response in Human 
      Osteoarthritic Chondrocytes.
PG  - 1151-9
LID - 10.1007/s10753-016-0349-8 [doi]
AB  - The pro-inflammatory cytokine interleukin-1beta (IL-1beta) plays critical roles in 
      pathogenesis of osteoarthritis (OA). Tormentic acid (TA), a triterpene isolated 
      from Rosa rugosa, has anti-inflammatory activity. However, the anti-inflammatory 
      effect of TA on OA is still unclear. So, in the present study, we examined the 
      effect of TA on IL-1beta-induced inflammatory response in primary human OA 
      chondrocytes. Our results demonstrated that TA significantly decreased the 
      IL-1beta-stimulated expression of matrix metalloproteinase-3 (MMP-3) and MMP-13. It 
      also inhibited the IL-1beta-induced expression of inducible nitric oxide (NO) 
      synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the production of NO and 
      prostaglandin E2 (PGE2) in human OA chondrocytes. Furthermore, TA greatly 
      inhibited the IL-1beta-induced NF-kappaB activation. In conclusion, this study is the 
      first to demonstrate the anti-inflammatory activity of TA in human OA 
      chondrocytes. TA significantly inhibits the IL-1beta-induced inflammatory response 
      by suppressing the NF-kappaB signaling pathway. Thus, TA may be a potential agent in 
      the treatment of OA.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Orthopedics, Tianjin Hospital, Tianjin, 300211, China.
FAU - Wang, Yawei
AU  - Wang Y
AD  - Department of Electromyography, Tianjin Hospital, Tianjin, 300211, China.
FAU - Wang, Yumin
AU  - Wang Y
AD  - Department of Orthopedics, Tianjin Hospital, Tianjin, 300211, China.
FAU - Zhao, Meng
AU  - Zhao M
AD  - Clinical laboratory, National Clinical Research Center for Cancer, Key Laboratory 
      of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and 
      Hospital, Tianjin, 300060, China.
FAU - Jia, Haobo
AU  - Jia H
AD  - Department of Orthopedics, Tianjin Hospital, Tianjin, 300211, China.
FAU - Li, Bing
AU  - Li B
AD  - Department of Orthopedics, Tianjin Hospital, Tianjin, 300211, China. 
      braveman1982@163.com.
FAU - Xing, Dan
AU  - Xing D
AD  - Arthritis Clinic & Research Center, Peking University People's Hospital, Peking 
      University, Beijing, 100044, China. xingdan@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Interleukin-18)
RN  - 0 (NF-kappa B)
RN  - 0 (Triterpenes)
RN  - 53155-25-2 (euscaphic acid)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Cells, Cultured
MH  - Chondrocytes/drug effects
MH  - Humans
MH  - Inflammation/chemically induced/*drug therapy
MH  - Interleukin-18/pharmacology
MH  - NF-kappa B/antagonists & inhibitors/metabolism
MH  - Osteoarthritis/drug therapy/*pathology
MH  - Signal Transduction/drug effects
MH  - Triterpenes/*pharmacology
OTO - NOTNLM
OT  - chondrocyte
OT  - interleukin-1beta (IL-1beta)
OT  - osteoarthritis (OA)
OT  - tormentic acid (TA)
EDAT- 2016/04/23 06:00
MHDA- 2017/03/10 06:00
CRDT- 2016/04/23 06:00
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
AID - 10.1007/s10753-016-0349-8 [pii]
AID - 10.1007/s10753-016-0349-8 [doi]
PST - ppublish
SO  - Inflammation. 2016 Jun;39(3):1151-9. doi: 10.1007/s10753-016-0349-8.