PMID- 27103017
OWN - NLM
STAT- MEDLINE
DCOM- 20170510
LR  - 20181113
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Print)
IS  - 0039-2499 (Linking)
VI  - 47
IP  - 6
DP  - 2016 Jun
TI  - Pial Collateral Reactivity During Hypertension and Aging: Understanding the 
      Function of Collaterals for Stroke Therapy.
PG  - 1618-25
LID - 10.1161/STROKEAHA.116.013392 [doi]
AB  - BACKGROUND AND PURPOSE: We investigated vasoactive properties of leptomeningeal 
      arterioles (LMAs) under normotensive conditions and during hypertension and aging 
      that are known to have poor collateral flow and little salvageable tissue. 
      METHODS: LMAs, identified as distal anastomotic arterioles connecting middle and 
      anterior cerebral arteries, were studied isolated and pressurized from young (18 
      weeks) or aged (48 weeks) normotensive Wistar Kyoto (WKY18, n=14; WKY48, n=6) 
      rats and spontaneously hypertensive rats (SHR18, n=16; SHR48, n=6). Myogenic tone 
      and vasoactive responses to pressure as well as endothelial function and ion 
      channel activity were measured. RESULTS: LMAs from WKY18 had little myogenic tone 
      at 40 mm Hg (8+/-3%) that increased in aged WKY48 (30+/-6%). However, LMAs from both 
      WKY groups dilated to increased pressure and demonstrated little myogenic 
      reactivity, a response that would be conducive to collateral flow. In contrast, 
      LMAs from both SHR18 and SHR48 displayed considerable myogenic tone (56+/-8% and 
      43+/-7%; P<0.01 versus WKY) and constricted to increased pressure. LMAs from both 
      WKY and SHR groups had similar basal endothelial nitric oxide and IK channel 
      activity that opposed tone. However, dilation to sodium nitroprusside, diltiazem 
      and 15 mmol/L KCl was impaired in LMAs from SHR18. CONCLUSIONS: This study shows 
      for the first time that LMAs from young and aged SHR are vasoconstricted and have 
      impaired vasodilatory responses that may contribute to greater perfusion deficit 
      and little penumbral tissue. These results also suggest that therapeutic opening 
      of pial collaterals is possible during middle cerebral artery occlusion to create 
      penumbral tissue and prevent infarct expansion.
CI  - (c) 2016 The Authors.
FAU - Chan, Siu-Lung
AU  - Chan SL
AD  - From the Departments of Neurological Sciences (S.-L.C., J.G.S., N.B., M.J.C.), 
      Obstetrics, Gynecology, and Reproductive Sciences (M.J.C.), and Pharmacology 
      (M.J.C.), University of Vermont College of Medicine, Burlington.
FAU - Sweet, Julie G
AU  - Sweet JG
AD  - From the Departments of Neurological Sciences (S.-L.C., J.G.S., N.B., M.J.C.), 
      Obstetrics, Gynecology, and Reproductive Sciences (M.J.C.), and Pharmacology 
      (M.J.C.), University of Vermont College of Medicine, Burlington.
FAU - Bishop, Nicole
AU  - Bishop N
AD  - From the Departments of Neurological Sciences (S.-L.C., J.G.S., N.B., M.J.C.), 
      Obstetrics, Gynecology, and Reproductive Sciences (M.J.C.), and Pharmacology 
      (M.J.C.), University of Vermont College of Medicine, Burlington.
FAU - Cipolla, Marilyn J
AU  - Cipolla MJ
AD  - From the Departments of Neurological Sciences (S.-L.C., J.G.S., N.B., M.J.C.), 
      Obstetrics, Gynecology, and Reproductive Sciences (M.J.C.), and Pharmacology 
      (M.J.C.), University of Vermont College of Medicine, Burlington. 
      marilyn.cipolla@uvm.edu.
LA  - eng
GR  - P01 HL095488/HL/NHLBI NIH HHS/United States
GR  - R01 NS093289/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160421
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Blood Vessels/*physiopathology
MH  - Cerebrovascular Circulation/*physiology
MH  - Collateral Circulation/*physiology
MH  - Disease Models, Animal
MH  - Hypertension/*physiopathology
MH  - Male
MH  - Pia Mater/*blood supply
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/therapy
MH  - Vasodilation/*physiology
PMC - PMC4878286
MID - NIHMS772975
OTO - NOTNLM
OT  - cerebrovascular circulation
OT  - hypertension
OT  - ion channel
OT  - nitric oxide
OT  - nitroprusside
OT  - potassium channels
OT  - stroke
EDAT- 2016/04/23 06:00
MHDA- 2017/05/11 06:00
PMCR- 2016/05/24
CRDT- 2016/04/23 06:00
PHST- 2016/03/07 00:00 [received]
PHST- 2016/03/22 00:00 [accepted]
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2017/05/11 06:00 [medline]
PHST- 2016/05/24 00:00 [pmc-release]
AID - STROKEAHA.116.013392 [pii]
AID - 10.1161/STROKEAHA.116.013392 [doi]
PST - ppublish
SO  - Stroke. 2016 Jun;47(6):1618-25. doi: 10.1161/STROKEAHA.116.013392. Epub 2016 Apr 
      21.