PMID- 27103387
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20220331
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 47
IP  - 6
DP  - 2016 Jun
TI  - Characterisation of patients with interstitial pneumonia with autoimmune 
      features.
PG  - 1767-75
LID - 10.1183/13993003.01565-2015 [doi]
AB  - Patients with interstitial lung disease (ILD) may have features of connective 
      tissue disease (CTD), but lack findings diagnostic of a specific CTD. A recent 
      European Respiratory Society/American Thoracic Society research statement 
      proposed criteria for patients with interstitial pneumonia with autoimmune 
      features (IPAF).We applied IPAF criteria to patients with idiopathic interstitial 
      pneumonia and undifferentiated CTD-ILD (UCTD). We then characterised the 
      clinical, serological and morphological features of the IPAF cohort, compared 
      outcomes to other ILD cohorts and validated individual IPAF domains using 
      survival as an endpoint.Of 422 patients, 144 met IPAF criteria. Mean age was 
      63.2 years with a slight female predominance. IPAF cohort survival was marginally 
      better than patients with idiopathic pulmonary fibrosis, but worse than CTD-ILD. 
      A non-usual interstitial pneumonia pattern was associated with improved survival, 
      as was presence of the clinical domain. A modified IPAF cohort of those meeting 
      the clinical domain and a radiographic or histological feature within the 
      morphological domain displayed survival similar to those with CTD-ILD.IPAF is 
      common among patients with idiopathic interstitial pneumonia and UCTD. Specific 
      IPAF features can identify subgroups with differential survival. Further research 
      is needed to replicate these findings and determine whether patients meeting IPAF 
      criteria benefit from immunosuppressive therapy.
CI  - Copyright (c)ERS 2016.
FAU - Oldham, Justin M
AU  - Oldham JM
AD  - Dept of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, The 
      University of California at Davis These authors contributed equally 
      joldham@ucdavis.edu.
FAU - Adegunsoye, Ayodeji
AU  - Adegunsoye A
AD  - Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University 
      of Chicago, Chicago, IL, USA These authors contributed equally.
FAU - Valenzi, Eleanor
AU  - Valenzi E
AD  - Dept of Medicine, The University of Chicago, Chicago, IL, USA.
FAU - Lee, Cathryn
AU  - Lee C
AD  - Dept of Medicine, The University of Chicago, Chicago, IL, USA.
FAU - Witt, Leah
AU  - Witt L
AD  - Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University 
      of Chicago, Chicago, IL, USA.
FAU - Chen, Lena
AU  - Chen L
AD  - Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University 
      of Chicago, Chicago, IL, USA.
FAU - Husain, Aliya N
AU  - Husain AN
AD  - Dept of Pathology, The University of Chicago, Chicago, IL, USA.
FAU - Montner, Steven
AU  - Montner S
AD  - Dept of Radiology, The University of Chicago, Chicago, IL, USA.
FAU - Chung, Jonathan H
AU  - Chung JH
AD  - Dept of Radiology, The University of Chicago, Chicago, IL, USA.
FAU - Cottin, Vincent
AU  - Cottin V
AD  - Dept of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, 
      University Claude Bernard Lyon, Lyon, France.
FAU - Fischer, Aryeh
AU  - Fischer A
AD  - Dept of Medicine, Division of Rheumatology, University of Colorado, Denver, CO, 
      USA.
FAU - Noth, Imre
AU  - Noth I
AD  - Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University 
      of Chicago, Chicago, IL, USA.
FAU - Vij, Rekha
AU  - Vij R
AD  - Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University 
      of Chicago, Chicago, IL, USA These authors contributed equally.
FAU - Strek, Mary E
AU  - Strek ME
AD  - Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University 
      of Chicago, Chicago, IL, USA These authors contributed equally.
LA  - eng
GR  - T32 HL007605/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160421
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Immunosuppressive Agents)
SB  - IM
CIN - Eur Respir J. 2016 Jun;47(6):1622-4. PMID: 27246077
CIN - Eur Respir J. 2016 Dec;48(6):1811-1813. PMID: 27903692
CIN - Eur Respir J. 2016 Dec;48(6):1813-1814. PMID: 27903693
EIN - Eur Respir J. 2017 May 11;49(5):. PMID: 28495685
MH  - Aged
MH  - Autoimmune Diseases/*diagnosis/*immunology
MH  - Biopsy
MH  - Cohort Studies
MH  - Connective Tissue Diseases/diagnosis/immunology
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*diagnosis/*immunology
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC5515625
MID - NIHMS877754
COIS- Conflict of interests: Disclosures can be found alongside the online version of 
      this article at erj.ersjournals.com
EDAT- 2016/04/23 06:00
MHDA- 2018/03/20 06:00
PMCR- 2017/07/18
CRDT- 2016/04/23 06:00
PHST- 2015/09/20 00:00 [received]
PHST- 2016/02/22 00:00 [accepted]
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/07/18 00:00 [pmc-release]
AID - 13993003.01565-2015 [pii]
AID - 10.1183/13993003.01565-2015 [doi]
PST - ppublish
SO  - Eur Respir J. 2016 Jun;47(6):1767-75. doi: 10.1183/13993003.01565-2015. Epub 2016 
      Apr 21.