PMID- 27103555
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160422
LR  - 20201001
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 7
IP  - 1
DP  - 2016 Jan
TI  - Heat shock protein 70 and anti-heat shock protein 70 antibodies in nasal 
      secretions of patients with chronic rhinosinusitis.
PG  - 14-20
LID - 10.2500/ar.2016.7.0149 [doi]
AB  - BACKGROUND: The issue of heat shock protein (HSP) 70 and anti-HSP70 antibodies in 
      chronic rhinosinusitis (CRS) has never been explored. OBJECTIVE: To determine the 
      nasal secretion (NS) levels of HSP70 and anti-HSP70 antibodies in patients with 
      CRS with nasal polyps (CRSwNP) and patients with CRS without nasal polyps 
      (CRSsNP), and to evaluate their associations with CRS clinical severity and 
      correlation with NS interleukin (IL), IL-5 and interferon lambda. METHODS: CRS 
      severity was determined by Lund-Mackay scores. Levels of immunoglobulin E (IgE), 
      IL-4, IL-5, interferon lambda, HSP70, and anti-HSP70 antibody levels in NS were 
      measured by enzyme-linked immunosorbent assay. RESULTS: Forty-six patients with 
      CRSsNP (25 women [54.3%] and 21 men [45.7%], mean [standard deviation SD]) age, 
      34.1 +/- 12.3 years; 54 patients with CRSwNP (24 women [44.4%] and 30 men [55.6%], 
      mean [SD] age, 37.9 +/- 17.5 years). A group of 40 healthy subjects served as 
      controls. Compared with the controls (with a mean [SD] NS HSP70 level of 0.05 +/- 
      0.03 mug/mL), mean [SD] NS HSP70 levels in both the CRSsNP group (0.16 +/- 0.07 
      mug/mL) and CRSwNP group (0.21 +/- 0.10 mug/mL) were increased (p < 0.001). 
      Similarly, the mean (SD) NS anti-HSP70 antibody levels were significantly higher 
      in patients with CRSwNP (0.25 +/- 0.09 optical density value [ODV]) compared with 
      CRSsNP (0.13 +/- 0.04 ODV) (p < 0.001) and healthy controls (0.14 +/- 0.02 ODV) (p < 
      0.001). NS HSP70 in subjects with CRSwNP showed a significant positive 
      correlation with the Lund-Mackay score (r = 0.31; p < 0.05). NS levels of either 
      HSP70 or anti-HSP70 antibodies were strongly correlated with NS IL-4 in the 
      CRSwNP group (r = 0.62, p < 0.001; and r = 0.69, p < 0.001, respectively). 
      CONCLUSION: NS concentrations of HSP70 and secretory IgA anti HSP70 antibodies 
      are increased in CRSwNP (but not in CRSsNP) and correlate positively with the 
      Lund-Mackay score, NS IL-4, and NS IL-5.
FAU - Tsybikov, Namjil N
AU  - Tsybikov NN
AD  - Pathophysiology Department, Chita Medical Academy, Chita, Russia.
FAU - Egorova, Elena V
AU  - Egorova EV
FAU - Kuznik, Boris I
AU  - Kuznik BI
FAU - Fefelova, Elena V
AU  - Fefelova EV
FAU - Magen, Eli
AU  - Magen E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC4837129
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2016/04/23 06:00
MHDA- 2016/04/23 06:01
PMCR- 2016/03/01
CRDT- 2016/04/23 06:00
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2016/04/23 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - AR050-15 [pii]
AID - 10.2500/ar.2016.7.0149 [doi]
PST - ppublish
SO  - Allergy Rhinol (Providence). 2016 Jan;7(1):14-20. doi: 10.2500/ar.2016.7.0149.