PMID- 27103670
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20201209
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 352
IP  - 6290
DP  - 2016 Jun 3
TI  - An endogenous caspase-11 ligand elicits interleukin-1 release from living 
      dendritic cells.
PG  - 1232-6
LID - 10.1126/science.aaf3036 [doi]
AB  - Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms 
      and activate protective immunity. These cells and receptors are thought to 
      operate in an all-or-nothing manner, existing in an immunologically active or 
      inactive state. Here, we report that encounters with microbial products and 
      self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation 
      state, which we call "hyperactive." Hyperactive DCs induce potent adaptive immune 
      responses and are elicited by caspase-11, an enzyme that binds oxPAPC and 
      bacterial lipopolysaccharide (LPS). oxPAPC and LPS bind caspase-11 via distinct 
      domains and elicit different inflammasome-dependent activities. Both lipids 
      induce caspase-11-dependent interleukin-1 release, but only LPS induces 
      pyroptosis. The cells and receptors of the innate immune system can therefore 
      achieve different activation states, which may permit context-dependent responses 
      to infection.
CI  - Copyright (c) 2016, American Association for the Advancement of Science.
FAU - Zanoni, Ivan
AU  - Zanoni I
AD  - Harvard Medical School and Division of Gastroenterology, Boston Children's 
      Hospital, Boston, MA, USA. Department of Biotechnology and Biosciences, 
      University of Milano-Bicocca, Milan, Italy. Unit of Cell Signalling and Innate 
      Immunity, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
FAU - Tan, Yunhao
AU  - Tan Y
AD  - Harvard Medical School and Division of Gastroenterology, Boston Children's 
      Hospital, Boston, MA, USA.
FAU - Di Gioia, Marco
AU  - Di Gioia M
AD  - Harvard Medical School and Division of Gastroenterology, Boston Children's 
      Hospital, Boston, MA, USA.
FAU - Broggi, Achille
AU  - Broggi A
AD  - Harvard Medical School and Division of Gastroenterology, Boston Children's 
      Hospital, Boston, MA, USA.
FAU - Ruan, Jianbin
AU  - Ruan J
AD  - Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical 
      School, Boston, MA, USA.
FAU - Shi, Jianjin
AU  - Shi J
AD  - National Institute of Biological Sciences, Beijing 102206, China.
FAU - Donado, Carlos A
AU  - Donado CA
AD  - Harvard Medical School and Division of Gastroenterology, Boston Children's 
      Hospital, Boston, MA, USA.
FAU - Shao, Feng
AU  - Shao F
AD  - National Institute of Biological Sciences, Beijing 102206, China.
FAU - Wu, Hao
AU  - Wu H
AD  - Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical 
      School, Boston, MA, USA. Program in Cellular and Molecular Medicine, Boston 
      Children's Hospital, Boston, MA, USA.
FAU - Springstead, James R
AU  - Springstead JR
AD  - Department of Chemical and Paper Engineering, Western Michigan University, 
      Kalamazoo, MI, USA.
FAU - Kagan, Jonathan C
AU  - Kagan JC
AD  - Harvard Medical School and Division of Gastroenterology, Boston Children's 
      Hospital, Boston, MA, USA. jonathan.kagan@childrens.harvard.edu.
LA  - eng
GR  - R01 AI093589/AI/NIAID NIH HHS/United States
GR  - AI072955/AI/NIAID NIH HHS/United States
GR  - R01 AI121066/AI/NIAID NIH HHS/United States
GR  - P30 DK034854/DK/NIDDK NIH HHS/United States
GR  - K99 AI072955/AI/NIAID NIH HHS/United States
GR  - P30 DK34854/DK/NIDDK NIH HHS/United States
GR  - 1R01AI121066-01A1/AI/NIAID NIH HHS/United States
GR  - 1R15HL121770-01A1/HL/NHLBI NIH HHS/United States
GR  - R15 HL121770/HL/NHLBI NIH HHS/United States
GR  - AI093589/AI/NIAID NIH HHS/United States
GR  - R00 AI072955/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160421
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Carrier Proteins)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Phospholipids)
RN  - 0 (Receptors, Pattern Recognition)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - EC 3.4.22.- (Casp4 protein, mouse)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (Caspases, Initiator)
SB  - IM
CIN - Science. 2016 Jun 3;352(6290):1173-4. PMID: 27257241
CIN - Nat Rev Immunol. 2016 Jul;16(7):404-5. PMID: 27320315
MH  - *Adaptive Immunity
MH  - Animals
MH  - Carrier Proteins/genetics/metabolism
MH  - Caspases/genetics/*immunology
MH  - Caspases, Initiator
MH  - Cell Death/immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Immunity, Innate
MH  - Inflammasomes/immunology
MH  - Interleukin-1beta/*metabolism
MH  - Lipopolysaccharides/*immunology
MH  - Mice
MH  - Mice, Knockout
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - Phospholipids/*metabolism
MH  - Receptors, Pattern Recognition/genetics/*immunology
MH  - Toll-Like Receptor 4/agonists/metabolism
PMC - PMC5111085
MID - NIHMS827368
EDAT- 2016/04/23 06:00
MHDA- 2016/06/28 06:00
PMCR- 2017/06/03
CRDT- 2016/04/23 06:00
PHST- 2016/01/22 00:00 [received]
PHST- 2016/04/13 00:00 [accepted]
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
PHST- 2017/06/03 00:00 [pmc-release]
AID - science.aaf3036 [pii]
AID - 10.1126/science.aaf3036 [doi]
PST - ppublish
SO  - Science. 2016 Jun 3;352(6290):1232-6. doi: 10.1126/science.aaf3036. Epub 2016 Apr 
      21.