PMID- 27104753
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 57
IP  - 10
DP  - 2016 Oct
TI  - Association between HLA-A1 and -A2 types and Epstein-Barr virus status of 
      post-transplant lymphoproliferative disorder.
PG  - 2351-8
LID - 10.3109/10428194.2016.1173209 [doi]
AB  - The susceptibility to Epstein-Barr virus (EBV)-related post-transplant 
      lymphoproliferative disorder (PTLD) may be affected by the human leukocyte 
      antigen (HLA) type. We investigated HLA-A and HLA-B allele frequencies, focusing 
      on HLA-A1 and -A2, in a population-based case series of EBV + (n = 60) and EBV- 
      (n = 44) PTLD after solid organ transplantation. The proportion of EBV + PTLD was 
      highest in HLA-A1 homozygotes (100%), lower in carriers of HLA-A1/AX (79%), 
      HLA-A1/A2 (55%), HLA-A2/AX (54%), and lowest in HLA-A2 homozygotes (37%). HLA-A1 
      type was overrepresented (22% versus 7%, p = 0.05) and HLA-A2 type 
      underrepresented (57% versus 80%, p = 0.01) in patients with EBV + compared with 
      EBV - PTLD. EBV + PTLD in HLA-A1 carriers developed almost exclusively in already 
      EBV-seropositive individuals. EBV status of PTLD was not related to any other 
      HLA-A or HLA-B type. Our findings suggest that HLA-A1 carriers may have an 
      increased risk of EBV + PTLD due to a decreased ability to control the latent EBV 
      infection.
FAU - Kinch, Amelie
AU  - Kinch A
AD  - a Department of Medical Sciences, Section of Infectious Diseases , Uppsala 
      University , Uppsala , Sweden ;
FAU - Sundstrom, Christer
AU  - Sundstrom C
AD  - b Department of Immunology, Genetics and Pathology, Pathology , Uppsala 
      University , Uppsala , Sweden ;
FAU - Tufveson, Gunnar
AU  - Tufveson G
AD  - c Department of Surgical Sciences , Uppsala University , Uppsala , Sweden ;
FAU - Glimelius, Ingrid
AU  - Glimelius I
AD  - d Department of Immunology, Genetics and Pathology, Experimental and Clinical 
      Oncology , Uppsala University , Uppsala , Sweden.
LA  - eng
PT  - Journal Article
DEP - 20160422
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (HLA-A1 Antigen)
RN  - 0 (HLA-A2 Antigen)
SB  - IM
CIN - Leuk Lymphoma. 2016 Oct;57(10):2241-2. PMID: 27379564
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Disease Susceptibility
MH  - Epstein-Barr Virus Infections/*complications/virology
MH  - Female
MH  - Genotype
MH  - HLA-A1 Antigen/*genetics/immunology
MH  - HLA-A2 Antigen/*genetics/immunology
MH  - *Herpesvirus 4, Human
MH  - Humans
MH  - Infant
MH  - Lymphoproliferative Disorders/diagnosis/*epidemiology/*etiology/mortality
MH  - Male
MH  - Middle Aged
MH  - Organ Transplantation/*adverse effects
MH  - Phenotype
MH  - Population Surveillance
MH  - Prognosis
MH  - Registries
MH  - Sweden/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - HLA type
OT  - PTLD
OT  - lymphoma
OT  - solid organ transplantation
EDAT- 2016/04/23 06:00
MHDA- 2017/12/23 06:00
CRDT- 2016/04/23 06:00
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
AID - 10.3109/10428194.2016.1173209 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2016 Oct;57(10):2351-8. doi: 10.3109/10428194.2016.1173209. Epub 
      2016 Apr 22.