PMID- 27105006
OWN - NLM
STAT- MEDLINE
DCOM- 20170822
LR  - 20180813
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 91
IP  - 5
DP  - 2016
TI  - Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in 
      Male Patients with Chronic Obstructive Pulmonary Disease.
PG  - 351-8
LID - 10.1159/000445266 [doi]
AB  - BACKGROUND: Vitamin D is suggested to play a role in airway and systemic 
      inflammation in chronic obstructive pulmonary disease (COPD). Low serum 
      25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with 
      lower lung function and poorer exercise capacity in COPD. OBJECTIVES: The main 
      purpose of this study was to investigate the effects of vitamin D deficiency on 
      the change in exercise capacity in male COPD patients. METHODS: A total of 156 
      male subjects were selected from the Korean Obstructive Lung Disease cohort. 
      Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and 
      severe deficiency groups. Rapid decline was defined as an annual rate of change 
      in exercise capacity >/=17 m. Exercise capacity was assessed by 6-minute walk 
      distance (6MWD). RESULTS: Significant differences were observed in the serum 
      levels of 25-OHD, the number of patients with vitamin D sufficiency, and 
      moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid 
      decliners (n = 116). No differences were found between the groups for age, 
      smoking status, lung function, and 6MWD. Multivariate analysis showed that 
      vitamin D deficiency was independently related to rapid decline in exercise 
      capacity (p = 0.028). A statistically significant difference was observed among 
      the subgroups of vitamin D deficiency in terms of the change in exercise capacity 
      (p < 0.001). The annual decline in exercise capacity was prominent in the severe 
      deficiency group (23.1 m/year). CONCLUSION: This study shows that vitamin D 
      deficiency is associated with rapid decline in exercise capacity in male patients 
      with COPD.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Kim, Changhwan
AU  - Kim C
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
FAU - Jung, Ji Ye
AU  - Jung JY
FAU - Kim, Young Sam
AU  - Kim YS
FAU - Lee, Jae Seung
AU  - Lee JS
FAU - Rhee, Chin Kook
AU  - Rhee CK
FAU - Lee, Jin Hwa
AU  - Lee JH
FAU - Lee, Ji-Hyun
AU  - Lee JH
FAU - Kim, Tae-Hyung
AU  - Kim TH
FAU - Lim, Seong Yong
AU  - Lim SY
FAU - Sheen, Seung Soo
AU  - Sheen SS
FAU - Yoo, Kwang Ha
AU  - Yoo KH
FAU - Seo, Joon Beom
AU  - Seo JB
FAU - Oh, Yeon-Mok
AU  - Oh YM
FAU - Lee, Sang-Do
AU  - Lee SD
FAU - Park, Yong Bum
AU  - Park YB
LA  - eng
PT  - Journal Article
DEP - 20160423
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Aged
MH  - Comorbidity
MH  - Disease Progression
MH  - Exercise Tolerance/*physiology
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Pulmonary Disease, Chronic Obstructive/epidemiology/*physiopathology
MH  - Republic of Korea/epidemiology
MH  - Smoking/epidemiology
MH  - Vital Capacity
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/*blood/epidemiology
MH  - Walk Test
EDAT- 2016/04/23 06:00
MHDA- 2017/08/23 06:00
CRDT- 2016/04/23 06:00
PHST- 2015/06/11 00:00 [received]
PHST- 2016/02/17 00:00 [accepted]
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2017/08/23 06:00 [medline]
AID - 000445266 [pii]
AID - 10.1159/000445266 [doi]
PST - ppublish
SO  - Respiration. 2016;91(5):351-8. doi: 10.1159/000445266. Epub 2016 Apr 23.