PMID- 27105501
OWN - NLM
STAT- MEDLINE
DCOM- 20180112
LR  - 20221207
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 20
DP  - 2016 May 17
TI  - Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a 
      Chinese population.
PG  - 29770-9
LID - 10.18632/oncotarget.8865 [doi]
AB  - Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes 
      Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As 
      HHEX is a recognized susceptibility gene in T2DM, this work was focused on two 
      SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM 
      patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), 
      cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) 
      cases were enrolled. DNA samples were extracted from the peripheral blood 
      leukocytes of the patients and sequenced by direct sequencing. The chi2 test was 
      used to compare categorical data. We found that in T2DM patients, rs1111875 but 
      not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 
      0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, 
      OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two 
      variants of HEEX gene could be risk factors for CRC in general population, 
      independent on T2DM (p< 0.001 for rs1111875, p=0.001 for rs7923837). For 
      rs1111875, increased risk of CRC was observed in TC or TC/CC than CC individuals 
      (p<0.001, OR= 1.780, 95%CI= 1.385-2.287; p<0.001, OR= 1.695, 95%CI= 1.335-2.152). 
      For rs7923837, increased CRC risk was observed in AG, GG, and AG/GG than AA 
      individuals (p< 0.001, OR= 1.520, 95%CI= 1.200-1.924; p=0.036, OR= 1.739, 95%CI= 
      0.989-3.058; p< 0.001, OR= 1.540, 95%CI= 1.225-1.936). This finding highlights 
      the potentially functional alteration with HHEX rs1111875 and rs7923837 
      polymorphisms may increase CRC susceptibility. Risk effects and the functional 
      impact of these polymorphisms need further validation.
FAU - Sun, Rui
AU  - Sun R
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Jian-Ping
AU  - Liu JP
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Gao, Chang
AU  - Gao C
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xiong, Ying-Ying
AU  - Xiong YY
AD  - Department of Clinical Laboratory, PuAi Hospital of Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Li, Min
AU  - Li M
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Ya-Ping
AU  - Wang YP
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Su, Yan-Wei
AU  - Su YW
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Lin, Mei
AU  - Lin M
AD  - Department of Endocrinology, Wuhan PuAi Hospital of Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Jiang, An-Li
AU  - Jiang AL
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xiong, Ling-Fan
AU  - Xiong LF
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xie, Yan
AU  - Xie Y
AD  - Department of Medicine, Washington University School of Medicine, St. Louis, 
      Missouri, United States of America.
FAU - Feng, Jue-Ping
AU  - Feng JP
AD  - Department of Oncology, PuAi Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (HHEX protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Asian People/genetics
MH  - Colorectal Neoplasms/*genetics
MH  - Diabetes Mellitus, Type 2/complications/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Transcription Factors/*genetics
PMC - PMC5045432
OTO - NOTNLM
OT  - HHEX
OT  - colorectal cancer
OT  - genetic variants
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest.
EDAT- 2016/04/23 06:00
MHDA- 2018/01/13 06:00
PMCR- 2016/05/17
CRDT- 2016/04/23 06:00
PHST- 2015/11/07 00:00 [received]
PHST- 2016/03/28 00:00 [accepted]
PHST- 2016/04/23 06:00 [entrez]
PHST- 2016/04/23 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/05/17 00:00 [pmc-release]
AID - 8865 [pii]
AID - 10.18632/oncotarget.8865 [doi]
PST - ppublish
SO  - Oncotarget. 2016 May 17;7(20):29770-9. doi: 10.18632/oncotarget.8865.