PMID- 27105589
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20171117
IS  - 1616-5195 (Electronic)
IS  - 1616-5187 (Linking)
VI  - 16
IP  - 8
DP  - 2016 Aug
TI  - Supramolecular Hydrogel from Nanoparticles and Cyclodextrins for Local and 
      Sustained Nanoparticle Delivery.
PG  - 1188-99
LID - 10.1002/mabi.201600076 [doi]
AB  - Injectable and biodegradable supramolecular hydrogel mPECT NP/alpha-CD(gel) composed 
      of high-concentration nanoparticle dispersion (</=20% W/V) and alpha-cyclodextrins 
      (alpha-CD) are prepared by a two-level physical cross-linking using amphiphilic block 
      polymer methoxy poly(ethylene 
      glycol)-b-poly(epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (mPECT) and 
      alpha-CD. The gelation behavior depends on the concentration of nanoparticles and 
      alpha-CD. The viscoelasticity and shear thinning of mPECT NP/alpha-CD(gel) are confirmed. 
      In vitro hydrogel erosion is demonstrated to be mainly a concentration-dependent 
      dissociation process with general release of discrete mPECT nanoparticles about 
      50 nm that can be easily taken up by cells. The in vitro release behavior can be 
      modulated by changing the concentration of nanoparticles or alpha-CD. In vitro and in 
      vivo cytotoxicity study demonstrates its biocompatibility and biosafety. Gel 
      formation after subcutaneous injection is also confirmed and mPECT NP/alpha-CD(gel) 
      shows about 2 weeks retention time. This work validates the potential application 
      for this supramolecular hydrogel in local and sustained delivery of 
      nanoparticles.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Xu, Shuxin
AU  - Xu S
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
FAU - Yin, Li
AU  - Yin L
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
FAU - Xiang, Yuzhang
AU  - Xiang Y
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
FAU - Deng, Hongzhang
AU  - Deng H
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
FAU - Deng, Liandong
AU  - Deng L
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
FAU - Fan, Hongxia
AU  - Fan H
AD  - Tianjin Life Science Research Center and School of basic medical sciences, 
      Tianjin Medical University, Tianjin, 300072, China.
FAU - Tang, Hua
AU  - Tang H
AD  - Tianjin Life Science Research Center and School of basic medical sciences, 
      Tianjin Medical University, Tianjin, 300072, China.
FAU - Zhang, Jianhua
AU  - Zhang J
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
FAU - Dong, Anjie
AU  - Dong A
AD  - Department of Polymer Science and Technology and Key Laboratory of Systems 
      Bioengineering of the Ministry of Education, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin, 300072, China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 
      Tianjin, 300072, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160423
PL  - Germany
TA  - Macromol Biosci
JT  - Macromolecular bioscience
JID - 101135941
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Ethylene Glycols)
RN  - 0 (Polyesters)
RN  - 0 (alpha-Cyclodextrins)
RN  - 0 (poly(epsilon-caprolactone)-b-poly(ethylene glycol))
RN  - 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate)
SB  - IM
MH  - Animals
MH  - Calorimetry, Differential Scanning
MH  - Cell Death
MH  - Cell Line, Tumor
MH  - Delayed-Action Preparations/*pharmacology
MH  - Endocytosis
MH  - Ethylene Glycols/chemical synthesis/chemistry
MH  - Humans
MH  - Hydrogel, Polyethylene Glycol Dimethacrylate/*chemistry
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/*chemistry
MH  - Polyesters/chemical synthesis/chemistry
MH  - X-Ray Diffraction
MH  - alpha-Cyclodextrins/*chemistry
OTO - NOTNLM
OT  - hydrogel
OT  - local delivery
OT  - nanoparticles
OT  - alpha-cyclodextrins
EDAT- 2016/04/24 06:00
MHDA- 2017/10/24 06:00
CRDT- 2016/04/24 06:00
PHST- 2016/03/07 00:00 [received]
PHST- 2016/03/25 00:00 [revised]
PHST- 2016/04/24 06:00 [entrez]
PHST- 2016/04/24 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
AID - 10.1002/mabi.201600076 [doi]
PST - ppublish
SO  - Macromol Biosci. 2016 Aug;16(8):1188-99. doi: 10.1002/mabi.201600076. Epub 2016 
      Apr 23.