PMID- 27105834
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20220409
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1860
IP  - 8
DP  - 2016 Aug
TI  - Relationship between ST8SIA2, polysialic acid and its binding molecules, and 
      psychiatric disorders.
PG  - 1739-52
LID - S0304-4165(16)30120-9 [pii]
LID - 10.1016/j.bbagen.2016.04.015 [doi]
AB  - Polysialic acid (polySia, PSA) is a unique and functionally important glycan, 
      particularly in vertebrate brains. It is involved in higher brain functions such 
      as learning, memory, and social behaviors. Recently, an association between 
      several genetic variations and single nucleotide polymorphisms (SNPs) of 
      ST8SIA2/STX, one of two polysialyltransferase genes in vertebrates, and 
      psychiatric disorders, such as schizophrenia (SZ), bipolar disorder (BD), and 
      autism spectrum disorder (ASD), was reported based on candidate gene approaches 
      and genome-wide studies among normal and mental disorder patients. It is of 
      critical importance to determine if the reported mutations and SNPs in ST8SIA2 
      lead to impairments of the structure and function of polySia, which is the final 
      product of ST8SIA2. To date, however, only a few such forward-directed studies 
      have been conducted. In addition, the molecular mechanisms underlying 
      polySia-involved brain functions remain unknown, although polySia was shown to 
      have an anti-adhesive effect. In this report, we review the relationships between 
      psychiatric disorders and polySia and/or ST8SIA2, and describe a new function of 
      polySia as a regulator of neurologically active molecules, such as brain-derived 
      neurotrophic factor (BDNF) and dopamine, which are deeply involved in psychiatric 
      disorders. This article is part of a Special Issue entitled "Glycans in 
      personalised medicine" Guest Editor: Professor Gordan Lauc.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Sato, Chihiro
AU  - Sato C
AD  - Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, 
      Japan. Electronic address: chi@agr.nagoya-u.ac.jp.
FAU - Hane, Masaya
AU  - Hane M
AD  - Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, 
      Japan.
FAU - Kitajima, Ken
AU  - Kitajima K
AD  - Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160420
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Sialic Acids)
RN  - 0 (polysialic acid)
RN  - EC 2.4.99.- (CMP-N-acetylneuraminate-poly-alpha-2,8-sialosyl sialyltransferase)
RN  - EC 2.4.99.- (Sialyltransferases)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Dopamine/genetics/metabolism
MH  - Genome-Wide Association Study
MH  - Humans
MH  - *Mental Disorders/genetics/metabolism
MH  - *Polymorphism, Single Nucleotide
MH  - *Sialic Acids/genetics/metabolism
MH  - *Sialyltransferases/genetics/metabolism
OTO - NOTNLM
OT  - Autism
OT  - Bipolar disorder
OT  - Neural cell adhesion molecule
OT  - Polysialic acid
OT  - Polysialyltransferase
OT  - Psychiatric disorder
OT  - SNPs
OT  - Schizophrenia
EDAT- 2016/04/24 06:00
MHDA- 2016/09/08 06:00
CRDT- 2016/04/24 06:00
PHST- 2015/12/12 00:00 [received]
PHST- 2016/04/15 00:00 [revised]
PHST- 2016/04/16 00:00 [accepted]
PHST- 2016/04/24 06:00 [entrez]
PHST- 2016/04/24 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
AID - S0304-4165(16)30120-9 [pii]
AID - 10.1016/j.bbagen.2016.04.015 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2016 Aug;1860(8):1739-52. doi: 
      10.1016/j.bbagen.2016.04.015. Epub 2016 Apr 20.