PMID- 27106507
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20180102
IS  - 2253-8070 (Electronic)
IS  - 2253-654X (Linking)
VI  - 35
IP  - 6
DP  - 2016 Nov-Dec
TI  - A comparative study of the target volume definition in radiotherapy with <<Slow CT 
      Scan>> vs. 4D PET/CT Scan in early stages non-small cell lung cancer.
PG  - 373-378
LID - S2253-654X(16)00025-1 [pii]
LID - 10.1016/j.remn.2016.02.003 [doi]
AB  - OBJECTIVES: To evaluate the use of 4D PET/CT to quantify tumor respiratory motion 
      compared to the <<Slow>>-CT (CTs) in the radiotherapy planning process. MATERIAL 
      AND METHODS: A total of 25 patients with inoperable early stage non small cell 
      lung cancer (NSCLC) were included in the study. Each patient was imaged with a 
      CTs (4s/slice) and 4D PET/CT. The adequacy of each technique for respiratory 
      motion capture was evaluated using the volume definition for each of the 
      following: Internal target volume (ITV) 4D and ITVslow in relation with the 
      volume defined by the encompassing volume of 4D PET/CT and CTs (ITVtotal). The 
      maximum distance between the edges of the volume defined by each technique to 
      that of the total volume was measured in orthogonal beam's eye view. RESULTS: The 
      ITV4D showed less differences in relation with the ITVtotal in both the 
      cranio-caudal and the antero-posterior axis compared to the ITVslow. The maximum 
      differences were 0.36mm in 4D PET/CTand 0.57mm in CTs in the antero-posterior 
      axis. 4D PET/CT resulted in the definition of more accurate (ITV4D/ITVtotal 0.78 
      vs. ITVs/ITVtotal 0.63), and larger ITVs (19.9 cc vs. 16.3 cc) than those 
      obtained with CTs. CONCLUSION: Planning with 4D PET/CT in comparison with CTs, 
      allows incorporating tumor respiratory motion and improving planning radiotherapy 
      of patients in early stages of lung cancer.
CI  - Copyright (c) 2016 Elsevier Espana, S.L.U. y SEMNIM. All rights reserved.
FAU - Molla, M
AU  - Molla M
AD  - Departamento de Oncologia Radioterapica, Hospital Universitario Vall d'Hebron, 
      Barcelona, Espana. Electronic address: meritxellmolla@gmail.com.
FAU - Anducas, N
AU  - Anducas N
AD  - Departamento de Fisica Medica, Hospital Universitario Vall d'Hebron, Barcelona, 
      Espana.
FAU - Simo, M
AU  - Simo M
AD  - Departamento de Medicina Nuclear, Hospital Universitario Vall d'Hebron, 
      Barcelona, Espana.
FAU - Seoane, A
AU  - Seoane A
AD  - Departamento de Fisica Medica, Hospital Universitario Vall d'Hebron, Barcelona, 
      Espana.
FAU - Ramos, M
AU  - Ramos M
AD  - Departamento de Oncologia Radioterapica, Hospital Universitario Vall d'Hebron, 
      Barcelona, Espana.
FAU - Cuberas-Borros, G
AU  - Cuberas-Borros G
AD  - Departamento de Medicina Nuclear, Hospital Universitario Vall d'Hebron, 
      Barcelona, Espana.
FAU - Beltran, M
AU  - Beltran M
AD  - Departamento de Fisica Medica, Hospital Universitario Vall d'Hebron, Barcelona, 
      Espana.
FAU - Castell, J
AU  - Castell J
AD  - Departamento de Medicina Nuclear, Hospital Universitario Vall d'Hebron, 
      Barcelona, Espana.
FAU - Giralt, J
AU  - Giralt J
AD  - Departamento de Oncologia Radioterapica, Hospital Universitario Vall d'Hebron, 
      Barcelona, Espana.
LA  - eng
LA  - spa
PT  - Comparative Study
PT  - Journal Article
TT  - Estudio comparativo en la definicion del volumen de tratamiento en radioterapia 
      con <<Slow TC Scan>> vs. 4D PET/TC Scan en estadios iniciales de cancer de pulmon 
      de celula no pequena.
DEP - 20160419
PL  - Spain
TA  - Rev Esp Med Nucl Imagen Mol
JT  - Revista espanola de medicina nuclear e imagen molecular
JID - 101585329
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/pathology/*radiotherapy
MH  - Female
MH  - *Four-Dimensional Computed Tomography/methods
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/pathology/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Positron Emission Tomography Computed Tomography
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Respiration
MH  - Time Factors
OTO - NOTNLM
OT  - 4D-PET/TC
OT  - Cancer de pulmon
OT  - Lung cancer
OT  - Planificacion del tratamiento
OT  - Radioterapia
OT  - Radiotherapy
OT  - Treatment planning
EDAT- 2016/11/05 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/04/24 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2016/01/13 00:00 [revised]
PHST- 2016/02/02 00:00 [accepted]
PHST- 2016/11/05 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2016/04/24 06:00 [entrez]
AID - S2253-654X(16)00025-1 [pii]
AID - 10.1016/j.remn.2016.02.003 [doi]
PST - ppublish
SO  - Rev Esp Med Nucl Imagen Mol. 2016 Nov-Dec;35(6):373-378. doi: 
      10.1016/j.remn.2016.02.003. Epub 2016 Apr 19.