PMID- 27107045
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20170817
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 50
IP  - 2
DP  - 2016 Aug
TI  - Quality of life of advanced chronic heart failure: medical care, mechanical 
      circulatory support and transplantation.
PG  - 269-73
LID - 10.1093/ejcts/ezw054 [doi]
AB  - OBJECTIVES: Advanced chronic heart failure (ACHF) is progressive with poor 
      prognosis and quality of life (QoL). Heart transplantation (HTx) is an effective 
      treatment for ACHF, but is limited by scarcity of donor hearts. Left ventricular 
      assist device (LVAD) support is a useful bridging therapy, and short- and 
      medium-term outcomes have improved. We investigated QoL in patients assessed for 
      HTx, awaiting HTx and after HTx. METHODS: We carried out a cross-sectional survey 
      across four groups: Group 1-patients assessed for HTx, Group 2-patients listed 
      for HTx on medical therapy, Group 3-patients supported with LVAD and Group 
      4-patients after HTx. Two questionnaires, the Kansas City Cardiomyopathy 
      Questionnaire (KCCQ) and the EuroQol dimensions (EQ-5D), were administered in all 
      adult HTx centres in the UK. Scores calculated for the KCCQ and EQ-5D were 
      compared. RESULTS: Three hundred and eighty-six patients completed 
      questionnaires: 194 in Group 1, 28 in Group 2, 82 in Group 3 and 82 in Group 4. 
      Patients after HTx reported the best QoL [KCCQ overall summary score: mean 73.0 
      (SD 27.2)]; patients with LVAD reported better QoL than those being assessed for 
      HTx and those listed for HTx on medical therapy [overall summary score; LVAD: 
      52.6 (22.0), Listed on medical therapy: 33.3 (21.1), ASSESSMENT: 35.5 (21.5)]. 
      Similarly, EQ-5D scores were highest in patients after HTx [HTx: mean 0.74 
      (0.27); LVAD: 0.58 (0.26), Listed on medical therapy: 0.44 (0.27), ASSESSMENT: 
      0.50 (SD 0.30)]. CONCLUSIONS: Patients supported with LVAD had a significantly 
      better QoL than those awaiting HTx without LVAD support, although HTx patients 
      reported the best QoL.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the European 
      Association for Cardio-Thoracic Surgery. All rights reserved.
FAU - Emin, Akan
AU  - Emin A
AD  - Clinical Effectiveness Unit, The Royal College of Surgeons of England, London, 
      UK.
FAU - Rogers, Chris A
AU  - Rogers CA
AD  - Clinical Effectiveness Unit, The Royal College of Surgeons of England, London, UK 
      Clinical Trials and Evaluation Unit, School of Clinical Sciences, University of 
      Bristol, Bristol, UK.
FAU - Banner, Nicholas R
AU  - Banner NR
AD  - Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield, 
      Middlesex, UK n.banner@rbht.nhs.uk.
CN  - Steering Group, UK Cardiothoracic Transplant Audit
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160422
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*psychology/surgery
MH  - *Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Extra corporeal membrane oxygenation
OT  - Heart failure
OT  - Heart transplantation
OT  - Mechanical circulatory support
OT  - Quality of life
OT  - Ventricular assist device
FIR - Hedger, Mike
IR  - Hedger M
FIR - Hards, Rachel
IR  - Hards R
FIR - Lincoln, Paul
IR  - Lincoln P
FIR - Wrightson, Neil
IR  - Wrightson N
FIR - Clarkson, Julie
IR  - Clarkson J
FIR - Robinson, Nicole
IR  - Robinson N
FIR - Beer, Sharon
IR  - Beer S
FIR - Lockhart, Jane
IR  - Lockhart J
FIR - Nuttall, Jane
IR  - Nuttall J
EDAT- 2016/04/24 06:00
MHDA- 2017/07/20 06:00
CRDT- 2016/04/24 06:00
PHST- 2015/03/22 00:00 [received]
PHST- 2016/01/25 00:00 [accepted]
PHST- 2016/04/24 06:00 [entrez]
PHST- 2016/04/24 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
AID - ezw054 [pii]
AID - 10.1093/ejcts/ezw054 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2016 Aug;50(2):269-73. doi: 10.1093/ejcts/ezw054. Epub 
      2016 Apr 22.