PMID- 27107676
OWN - NLM
STAT- MEDLINE
DCOM- 20171129
LR  - 20171129
IS  - 1879-0534 (Electronic)
IS  - 0010-4825 (Linking)
VI  - 73
DP  - 2016 Jun 1
TI  - Novel risk index for the identification of age-related macular degeneration using 
      radon transform and DWT features.
PG  - 131-40
LID - S0010-4825(16)30098-1 [pii]
LID - 10.1016/j.compbiomed.2016.04.009 [doi]
AB  - Age-related Macular Degeneration (AMD) affects the central vision of aged people. 
      It can be diagnosed due to the presence of drusen, Geographic Atrophy (GA) and 
      Choroidal Neovascularization (CNV) in the fundus images. It is labor intensive 
      and time-consuming for the ophthalmologists to screen these images. An automated 
      digital fundus photography based screening system can overcome these drawbacks. 
      Such a safe, non-contact and cost-effective platform can be used as a screening 
      system for dry AMD. In this paper, we are proposing a novel algorithm using Radon 
      Transform (RT), Discrete Wavelet Transform (DWT) coupled with Locality Sensitive 
      Discriminant Analysis (LSDA) for automated diagnosis of AMD. First the image is 
      subjected to RT followed by DWT. The extracted features are subjected to 
      dimension reduction using LSDA and ranked using t-test. The performance of 
      various supervised classifiers namely Decision Tree (DT), Support Vector Machine 
      (SVM), Probabilistic Neural Network (PNN) and k-Nearest Neighbor (k-NN) are 
      compared to automatically discriminate to normal and AMD classes using ranked 
      LSDA components. The proposed approach is evaluated using private and public 
      datasets such as ARIA and STARE. The highest classification accuracy of 99.49%, 
      96.89% and 100% are reported for private, ARIA and STARE datasets. Also, AMD 
      index is devised using two LSDA components to distinguish two classes accurately. 
      Hence, this proposed system can be extended for mass AMD screening.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Acharya, U Rajendra
AU  - Acharya UR
AD  - Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, 
      Singapore; Department of Biomedical Engineering, School of Science and 
      Technology, SIM University, 599491, Singapore; Department of Biomedical 
      Engineering, Faculty of Engineering, University of Malaya, 50603, Malaysia.
FAU - Mookiah, Muthu Rama Krishnan
AU  - Mookiah MR
AD  - Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, 
      Singapore. Electronic address: mkm2@np.edu.sg.
FAU - Koh, Joel E W
AU  - Koh JE
AD  - Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, 
      Singapore.
FAU - Tan, Jen Hong
AU  - Tan JH
AD  - Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, 
      Singapore.
FAU - Noronha, Kevin
AU  - Noronha K
AD  - Department of Electronics and Telecommunication, St. Francis Institute of 
      Technology, Mumbai 400103, India.
FAU - Bhandary, Sulatha V
AU  - Bhandary SV
AD  - Department of Ophthalmology, Kasturba Medical College, Manipal 576104, India.
FAU - Rao, A Krishna
AU  - Rao AK
AD  - Department of Ophthalmology, Kasturba Medical College, Manipal 576104, India.
FAU - Hagiwara, Yuki
AU  - Hagiwara Y
AD  - Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, 
      Singapore.
FAU - Chua, Chua Kuang
AU  - Chua CK
AD  - Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, 
      Singapore.
FAU - Laude, Augustinus
AU  - Laude A
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 308433, 
      Singapore.
LA  - eng
PT  - Journal Article
DEP - 20160422
PL  - United States
TA  - Comput Biol Med
JT  - Computers in biology and medicine
JID - 1250250
SB  - IM
MH  - *Algorithms
MH  - Choroidal Neovascularization/*diagnostic imaging
MH  - *Databases, Factual
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Macular Degeneration/*diagnostic imaging
MH  - Male
MH  - Risk Assessment
MH  - *Support Vector Machine
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Computed aided diagnosis
OT  - Discrete wavelet transform
OT  - Fundus imaging
OT  - Locality sensitive discriminant analysis
OT  - Radon transform
EDAT- 2016/04/25 06:00
MHDA- 2017/12/01 06:00
CRDT- 2016/04/25 06:00
PHST- 2016/02/17 00:00 [received]
PHST- 2016/04/10 00:00 [revised]
PHST- 2016/04/14 00:00 [accepted]
PHST- 2016/04/25 06:00 [entrez]
PHST- 2016/04/25 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
AID - S0010-4825(16)30098-1 [pii]
AID - 10.1016/j.compbiomed.2016.04.009 [doi]
PST - ppublish
SO  - Comput Biol Med. 2016 Jun 1;73:131-40. doi: 10.1016/j.compbiomed.2016.04.009. 
      Epub 2016 Apr 22.