PMID- 27107757
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20211204
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 104
IP  - 1
DP  - 2016 Jul
TI  - Immunosuppressive therapy for patients with Down syndrome and idiopathic aplastic 
      anemia.
PG  - 130-3
LID - 10.1007/s12185-016-1997-z [doi]
AB  - Idiopathic aplastic anemia (AA) is a rare hematological complication of Down 
      syndrome (DS). The safety and efficacy of immunosuppressive therapy (IST) in 
      individuals with DS remain unknown. We used a standard regimen of IST, comprising 
      antithymocyte globulin and cyclosporine A, to treat three children with DS and 
      idiopathic acquired AA. Two patients achieved a hematological (complete or 
      partial) response and became transfusion independent at the final follow-up. The 
      third patient failed to respond to IST and underwent bone marrow transplantation 
      from a human leukocyte antigen (HLA)-mismatched unrelated donor. None of the 
      patients experienced severe or unexpected adverse events during IST. Our 
      experience suggests that IST is a safe and reasonable treatment, even in 
      individuals with DS who suffer from AA and lack an HLA-matched sibling donor.
FAU - Suzuki, Kyogo
AU  - Suzuki K
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan.
FAU - Muramatsu, Hideki
AU  - Muramatsu H
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan.
FAU - Okuno, Yusuke
AU  - Okuno Y
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan.
FAU - Narita, Atsushi
AU  - Narita A
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan.
FAU - Hama, Asahito
AU  - Hama A
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan.
FAU - Takahashi, Yoshiyuki
AU  - Takahashi Y
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan.
FAU - Yoshida, Makoto
AU  - Yoshida M
AD  - Department of Pediatrics, Japanese Red Cross Asahikawa Hospital, Asahikawa, 
      Japan.
FAU - Horikoshi, Yasuo
AU  - Horikoshi Y
AD  - Division of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka, 
      Japan.
FAU - Watanabe, Ken-Ichiro
AU  - Watanabe K
AD  - Division of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka, 
      Japan.
FAU - Kudo, Kazuko
AU  - Kudo K
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Japan.
FAU - Kojima, Seiji
AU  - Kojima S
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho, Showa-ku, Nagoya, 4668550, Japan. kojimas@med.nagoya-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20160423
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Anemia, Aplastic/etiology/*therapy
MH  - Antilymphocyte Serum/therapeutic use
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Cyclosporine/therapeutic use
MH  - Down Syndrome/complications/*therapy
MH  - Humans
MH  - Immunosuppression Therapy/methods
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aplastic anemia
OT  - Down syndrome
OT  - Immunosuppressive therapy
EDAT- 2016/04/25 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/04/25 06:00
PHST- 2016/02/04 00:00 [received]
PHST- 2016/03/29 00:00 [accepted]
PHST- 2016/03/29 00:00 [revised]
PHST- 2016/04/25 06:00 [entrez]
PHST- 2016/04/25 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
AID - 10.1007/s12185-016-1997-z [pii]
AID - 10.1007/s12185-016-1997-z [doi]
PST - ppublish
SO  - Int J Hematol. 2016 Jul;104(1):130-3. doi: 10.1007/s12185-016-1997-z. Epub 2016 
      Apr 23.