PMID- 27108476
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20221207
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 87
IP  - 8
DP  - 2016 Aug
TI  - Systemic Inflammatory Biomarkers and Their Association With Periodontal and 
      Diabetes-Related Factors in the Diabetes and Periodontal Therapy Trial, A 
      Randomized Controlled Trial.
PG  - 900-13
LID - 10.1902/jop.2016.150727 [doi]
AB  - BACKGROUND: The present study evaluates effects of non-surgical periodontal 
      treatment on serum biomarkers in patients with type 2 diabetes mellitus (t2DM) 
      and chronic periodontitis who participated in the Diabetes and Periodontal 
      Therapy Trial (DPTT); and associations among diabetes markers, serum biomarkers, 
      and periodontal measures in these patients. METHODS: DPTT participants randomized 
      to receive immediate or delayed non-surgical periodontal therapy were evaluated 
      at baseline and 6 months. Serum samples from 475 participants with 6-month data 
      were analyzed for the following biomarkers: 1) high sensitivity C-reactive 
      protein; 2) E-selectin; 3) tumor necrosis factor (TNF)-alpha; 4) vascular cell 
      adhesion molecule (VCAM); 5) interleukin (IL)-6; 6) IL-8; 7) intercellular 
      adhesion molecule; and 8) IL-10. Changes in biomarker levels from baseline and 
      correlations among biomarker levels and clinical findings were analyzed. RESULTS: 
      No differences between treatment and control groups were observed for any 
      biomarkers at baseline or 6 months (P >0.05 for all variables). VCAM levels 
      increased by an average (standard deviation) of 17.9 (99.5); ng/mL (P = 0.006) 
      and E-selectin decreased by 2.33 (16.08) ng/mL (P = 0.03) in the treatment group 
      after 6 months. E-selectin levels were significantly correlated with DM-related 
      variables (hemoglobin A1c [HbA1c] and fasting glucose) at baseline and with 
      6-month change in both groups; no significant correlations were found among 
      periodontal clinical parameters and serum biomarkers or DM-related variables. 
      Neither HbA1c or body mass index varied during the study period in either study 
      group. CONCLUSIONS: Non-surgical periodontal therapy and periodontal disease 
      severity were not associated with significant changes in serum biomarkers in DPTT 
      participants during the 6-month follow-up. Correlations among changes in 
      E-selectin, IL-6, and DM-related variables suggest that t2DM may be the primary 
      driver of systemic inflammation in these patients.
FAU - Geisinger, Maria L
AU  - Geisinger ML
AD  - Department of Periodontology, University of Alabama at Birmingham, Birmingham, 
      AL.
FAU - Michalowicz, Bryan S
AU  - Michalowicz BS
AD  - Department of Developmental and Surgical Sciences, University of Minnesota, 
      Minneapolis, MN.
FAU - Hou, Wei
AU  - Hou W
AD  - Department of Family, Population and Preventive Medicine, Stony Brook University, 
      Stony Brook, NY.
FAU - Schoenfeld, Elinor
AU  - Schoenfeld E
AD  - Department of Family, Population and Preventive Medicine, Stony Brook University, 
      Stony Brook, NY.
FAU - Gelato, Marie
AU  - Gelato M
AD  - Department of Endocrinology, Stony Brook University.
FAU - Engebretson, Steven P
AU  - Engebretson SP
AD  - Department of Periodontology and Implant Dentistry, New York University, New 
      York, NY.
FAU - Reddy, Michael S
AU  - Reddy MS
AD  - Department of Periodontics, University of Alabama at Birmingham.
FAU - Hyman, Leslie
AU  - Hyman L
AD  - Department of Family, Population and Preventive Medicine, Stony Brook University, 
      Stony Brook, NY.
LA  - eng
SI  - ClinicalTrials.gov/NCT00997178
GR  - U01 DE018886/DE/NIDCR NIH HHS/United States
GR  - U01 DE018902/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160425
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - J Periodontol. 2016 Oct;87(10):1113-6. PMID: 27677805
MH  - *Biomarkers
MH  - Dental Scaling
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Interleukin-6/blood
MH  - Periodontitis/*complications
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - *Biomarkers
OT  - *cytokines
OT  - *diabetes mellitus, periodontal diseases
OT  - *periodontitis
EDAT- 2016/04/26 06:00
MHDA- 2018/05/08 06:00
CRDT- 2016/04/26 06:00
PHST- 2016/04/26 06:00 [entrez]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
AID - 10.1902/jop.2016.150727 [doi]
PST - ppublish
SO  - J Periodontol. 2016 Aug;87(8):900-13. doi: 10.1902/jop.2016.150727. Epub 2016 Apr 
      25.