PMID- 27108915
OWN - NLM
STAT- MEDLINE
DCOM- 20170301
LR  - 20220317
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 49
IP  - 2
DP  - 2017 Mar
TI  - Testicular versus ejaculated spermatozoa in ICSI cycles of normozoospermic men 
      with high sperm DNA fragmentation and previous ART failures.
LID - 10.1111/and.12609 [doi]
AB  - As a part of male assessment, conventional sperm parameters including morphologic 
      features have been dedicated as major factors influencing fertilisation and 
      pregnancy rates in assisted reproductive technology (ART). Genomic integrity of 
      spermatozoa has also been found to influence fertility prognosis, and hence, 
      sperm DNA fragmentation index (DFI) has been adopted by many centres to document 
      this entity. Despite several suggested approaches, there is lack of universal 
      consensus on optimising fertility outcomes in males with high sperm DFI. In this 
      context, the results from cycles using testicular spermatozoa (TESA) obtained by 
      aspiration were compared with those of ejaculated spermatozoa (EJ) in 
      normozoospermic subjects with high sperm DFI and previous ART failures. Clinical 
      (41.9% versus 20%) and ongoing pregnancy rates (38.7% versus 15%) were 
      significantly better and miscarriages were lower in TESA group when compared to 
      EJ group. Sperm DFI should be a part of male partner's evaluation following 
      unsuccessful ART attempts. When high DFI is detected (>30%), ICSI using 
      testicular spermatozoa obtained by TESA seems an effective option particularly 
      for those with repeated ART failures in terms of clinical, ongoing pregnancies 
      and miscarriages even though conventional sperm parameters are within normal 
      range.
CI  - (c) 2016 Blackwell Verlag GmbH.
FAU - Pabuccu, E G
AU  - Pabuccu EG
AD  - Ufuk University School of Medicine, Department of Obstetrics and Gynecology, 
      Ankara, Turkey.
FAU - Caglar, G S
AU  - Caglar GS
AD  - Ufuk University School of Medicine, Department of Obstetrics and Gynecology, 
      Ankara, Turkey.
FAU - Tangal, S
AU  - Tangal S
AD  - Ufuk University School of Medicine, Department of Urology, Ankara, Turkey.
FAU - Haliloglu, A H
AU  - Haliloglu AH
AD  - Ufuk University School of Medicine, Department of Urology, Ankara, Turkey.
FAU - Pabuccu, R
AU  - Pabuccu R
AD  - Ufuk University School of Medicine, Department of Obstetrics and Gynecology, 
      Ankara, Turkey.
AD  - Centrum Clinic Women's Health and ART Center, Ankara, Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160425
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
SB  - IM
MH  - Abortion, Spontaneous/epidemiology
MH  - Adult
MH  - *DNA Fragmentation
MH  - *Ejaculation
MH  - Female
MH  - Fertility
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Pregnancy Rate
MH  - Semen Analysis
MH  - Sperm Injections, Intracytoplasmic/*methods
MH  - *Sperm Retrieval
MH  - Spermatozoa/*metabolism
MH  - Testis/*cytology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Assisted reproductive technology
OT  - ejaculate
OT  - intra-cytoplasmic sperm injection
OT  - sperm DNA
OT  - testicular sperm aspiration
EDAT- 2016/04/26 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/04/26 06:00
PHST- 2016/03/19 00:00 [accepted]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2016/04/26 06:00 [entrez]
AID - 10.1111/and.12609 [doi]
PST - ppublish
SO  - Andrologia. 2017 Mar;49(2). doi: 10.1111/and.12609. Epub 2016 Apr 25.