PMID- 27108933
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180816
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 110
IP  - Pt A
DP  - 2016 Nov
TI  - The effect of serum BDNF levels on central serotonin transporter availability in 
      obese versus non-obese adults: A [(11)C]DASB positron emission tomography study.
PG  - 530-536
LID - S0028-3908(16)30170-8 [pii]
LID - 10.1016/j.neuropharm.2016.04.030 [doi]
AB  - BACKGROUND: Serotonin (5-HT) and its neurotrophic support system, specifically 
      brain-derived neurotrophic factor (BDNF), are thought to modulate energy 
      homeostasis and susceptibility to obesity. Moreover, a polymorphism (5-HTTLPR) in 
      the serotonin reuptake transporter (5-HTT) gene impairs its transcription, 
      thereby altering serotonergic tone and potentially contributing to such 
      susceptibility. This study aims to investigate the effect of BDNF, biallelic 
      5-HTTLPR, and central in-vivo 5-HTT availability in highly obese versus non-obese 
      subjects using positron emission tomography (PET) and 5-HTT selective 
      [(11)C]DASB. METHODS: Thirty-eight subjects, 24 obese, otherwise mentally and 
      physically healthy, and 14 non-obese healthy controls were included in this 
      study. Parametric images of binding potential were generated from PET data. 
      Central 5-HTT availability, 5-HTTLPR genotype, and serum BDNF concentrations were 
      analyzed, first in a volume of interest, then in a voxel-wise manner. RESULTS: 
      Overall, our results showed an absence of a linear correlation between BDNF, 
      in-vivo central 5-HTT availability, and body mass index (BMI). 5-HTTLPR 
      genotyping revealed BDNF and hippocampal 5-HTT availability to be negatively 
      correlated (r = -0.57, p = 0.007) in long allelic homozygotes. However, obese 
      subjects exhibited opposing effects of BDNF levels on 5-HTT availability in the 
      nucleus accumbens (NAcc) relative to our non-obese controls. CONCLUSIONS: Our 
      data did not confirm an overall correlation between serum BDNF, in-vivo central 
      5-HTT availability, 5-HTTLPR, and BMI. However, there is evidence that 
      serotonergic tone linked to BDNF, specifically in the NAcc, is involved in the 
      pathophysiology of obesity, although this needs further exploration over a wide 
      range of reward-related eating behaviors.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Hinderberger, Philipp
AU  - Hinderberger P
AD  - Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; 
      Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Rullmann, Michael
AU  - Rullmann M
AD  - Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; 
      Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Drabe, Mandy
AU  - Drabe M
AD  - Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Luthardt, Julia
AU  - Luthardt J
AD  - Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
FAU - Becker, Georg-Alexander
AU  - Becker GA
AD  - Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
FAU - Bluher, Matthias
AU  - Bluher M
AD  - Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Regenthal, Ralf
AU  - Regenthal R
AD  - Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and 
      Toxicology, University of Leipzig, Leipzig, Germany.
FAU - Sabri, Osama
AU  - Sabri O
AD  - Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; 
      Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Hesse, Swen
AU  - Hesse S
AD  - Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; 
      Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of 
      Leipzig, Leipzig, Germany. Electronic address: Swen.Hesse@medizin.uni-leipzig.de.
LA  - eng
PT  - Journal Article
DEP - 20160422
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile)
RN  - 0 (Aniline Compounds)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Sulfides)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aniline Compounds
MH  - Body Mass Index
MH  - Brain/diagnostic imaging/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/diagnostic imaging/*genetics/*metabolism
MH  - Positron-Emission Tomography
MH  - Radiopharmaceuticals
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics/*metabolism
MH  - Sulfides
MH  - Young Adult
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Energy homeostasis
OT  - Neurotrophin
OT  - Obesity
OT  - Positron emission tomography
OT  - Serotonergic tone
OT  - Serotonin
OT  - Serotonin transporter
OT  - Serotonin-transporter-linked polymorphic region
EDAT- 2016/04/26 06:00
MHDA- 2018/02/23 06:00
CRDT- 2016/04/26 06:00
PHST- 2015/07/22 00:00 [received]
PHST- 2016/02/26 00:00 [revised]
PHST- 2016/04/20 00:00 [accepted]
PHST- 2016/04/26 06:00 [entrez]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
AID - S0028-3908(16)30170-8 [pii]
AID - 10.1016/j.neuropharm.2016.04.030 [doi]
PST - ppublish
SO  - Neuropharmacology. 2016 Nov;110(Pt A):530-536. doi: 
      10.1016/j.neuropharm.2016.04.030. Epub 2016 Apr 22.