PMID- 27108934
OWN - NLM
STAT- MEDLINE
DCOM- 20170707
LR  - 20180207
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 108
DP  - 2016 Sep
TI  - Behavioral, neurochemical and molecular changes after acute deep brain 
      stimulation of the infralimbic prefrontal cortex.
PG  - 91-102
LID - S0028-3908(16)30159-9 [pii]
LID - 10.1016/j.neuropharm.2016.04.020 [doi]
AB  - Deep brain stimulation (DBS) is a treatment that has shown some efficacy in 
      treatment-resistant depression. In particular, DBS of the subcallosal cingulate 
      gyrus (Brodmann's area 25, Cg25) has been successfully applied to treat 
      refractory depression. In the rat, we have demonstrated that DBS applied to 
      infralimbic (IL) cortex elevates the levels of glutamate and monoamines in the 
      prefrontal cortex, and requires the stimulation of cortical 
      alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors 
      for its antidepressant-like effects. However, the molecular targets of IL DBS are 
      not fully known. To gain insight into these pathways, we have investigated 
      whether IL DBS is able to reverse the behavioral, biochemical and molecular 
      changes exhibited by the olfactory bulbectomized (OBX) rat. Our results revealed 
      that 1 h IL DBS diminished hyperlocomotion, hyperemotionality and anhedonia, and 
      increased social interaction shown by the OBX rats. Further, IL DBS increased 
      prefrontal efflux of glutamate and serotonin in both sham-operated and OBX rats. 
      With regard to molecular targets, IL DBS increases the synthesis of brain-derived 
      neurotrophic factor (BDNF) and the GluA1 AMPA receptor subunit, and stimulates 
      the Akt/mammalian target of rapamycin (mTOR) as well as the AMPA receptor/c-AMP 
      response element binding (CREB) pathways. Temsirolimus, a known in vivo mTOR 
      blocker, suppressed the antidepressant-like effect of IL DBS in naive rats in the 
      forced swim test, thus demonstrating for the first time that mTOR signaling is 
      required for the antidepressant-like effects of IL DBS, which is in line with the 
      antidepressant response of other rapid-acting antidepressant drugs.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Jimenez-Sanchez, Laura
AU  - Jimenez-Sanchez L
AD  - Departamento de Neuroquimica y Neurofarmacologia, Instituto de Investigaciones 
      Biomedicas de Barcelona (CSIC, IDIBAPS), 08036 Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain.
FAU - Linge, Raquel
AU  - Linge R
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain; 
      Instituto de Biomedicina y Biotecnologia de Cantabria, IBBTEC (CSIC, Universidad 
      de Cantabria), 39011 Santander, Spain.
FAU - Campa, Leticia
AU  - Campa L
AD  - Departamento de Neuroquimica y Neurofarmacologia, Instituto de Investigaciones 
      Biomedicas de Barcelona (CSIC, IDIBAPS), 08036 Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain.
FAU - Valdizan, Elsa M
AU  - Valdizan EM
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain; 
      Instituto de Biomedicina y Biotecnologia de Cantabria, IBBTEC (CSIC, Universidad 
      de Cantabria), 39011 Santander, Spain.
FAU - Pazos, Angel
AU  - Pazos A
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain; 
      Instituto de Biomedicina y Biotecnologia de Cantabria, IBBTEC (CSIC, Universidad 
      de Cantabria), 39011 Santander, Spain.
FAU - Diaz, Alvaro
AU  - Diaz A
AD  - Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain; 
      Instituto de Biomedicina y Biotecnologia de Cantabria, IBBTEC (CSIC, Universidad 
      de Cantabria), 39011 Santander, Spain.
FAU - Adell, Albert
AU  - Adell A
AD  - Departamento de Neuroquimica y Neurofarmacologia, Instituto de Investigaciones 
      Biomedicas de Barcelona (CSIC, IDIBAPS), 08036 Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Spain; Instituto de 
      Biomedicina y Biotecnologia de Cantabria, IBBTEC (CSIC, Universidad de 
      Cantabria), 39011 Santander, Spain. Electronic address: albert.adell@unican.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160421
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Deep Brain Stimulation/*methods
MH  - Depression/*metabolism/surgery
MH  - *Interpersonal Relations
MH  - Male
MH  - Olfactory Bulb/chemistry/metabolism/surgery
MH  - Prefrontal Cortex/*chemistry/*metabolism/surgery
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Antidepressant
OT  - Deep brain stimulation
OT  - Glutamate
OT  - Olfactory bulbectomy
OT  - Serotonin
EDAT- 2016/04/26 06:00
MHDA- 2017/07/08 06:00
CRDT- 2016/04/26 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/04/12 00:00 [revised]
PHST- 2016/04/14 00:00 [accepted]
PHST- 2016/04/26 06:00 [entrez]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2017/07/08 06:00 [medline]
AID - S0028-3908(16)30159-9 [pii]
AID - 10.1016/j.neuropharm.2016.04.020 [doi]
PST - ppublish
SO  - Neuropharmacology. 2016 Sep;108:91-102. doi: 10.1016/j.neuropharm.2016.04.020. 
      Epub 2016 Apr 21.