PMID- 27110438
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20211025
IS  - 2162-3279 (Electronic)
VI  - 6
IP  - 1
DP  - 2016 Jan
TI  - Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic 
      brain injury, and combat exposure contribute to postdeployment traumatic stress.
PG  - e00392
LID - 10.1002/brb3.392 [doi]
LID - e00392
AB  - BACKGROUND: In addition to experiencing traumatic events while deployed in a 
      combat environment, there are other factors that contribute to the development of 
      posttraumatic stress disorder (PTSD) in military service members. This study 
      explored the contribution of genetics, childhood environment, prior trauma, 
      psychological, cognitive, and deployment factors to the development of traumatic 
      stress following deployment. METHODS: Both pre- and postdeployment data on 231 of 
      458 soldiers were analyzed. Postdeployment assessments occurred within 30 days 
      from returning stateside and included a battery of psychological health, medical 
      history, and demographic questionnaires; neurocognitive tests; and blood serum 
      for the D2 dopamine receptor (DRD2), apolipoprotein E (APOE), and brain-derived 
      neurotropic factor (BDNF) genes. RESULTS: Soldiers who screened positive for 
      traumatic stress at postdeployment had significantly higher scores in depression 
      (d = 1.91), anxiety (d = 1.61), poor sleep quality (d = 0.92), postconcussion 
      symptoms (d = 2.21), alcohol use (d = 0.63), traumatic life events (d = 0.42), 
      and combat exposure (d = 0.91). BDNF Val66 Met genotype was significantly 
      associated with risk for sustaining a mild traumatic brain injury (mTBI) and 
      screening positive for traumatic stress. Predeployment traumatic stress, greater 
      combat exposure and sustaining an mTBI while deployed, and the BDNF Met/Met 
      genotype accounted for 22% of the variance of postdeployment PTSD scores (R (2) 
       = 0.22, P < 0.001). However, predeployment traumatic stress, alone, accounted 
      for 17% of the postdeployment PTSD scores. CONCLUSION: These findings suggest 
      predeployment traumatic stress, genetic, and environmental factors have unique 
      contributions to the development of combat-related traumatic stress in military 
      service members.
FAU - Dretsch, Michael N
AU  - Dretsch MN
AD  - U.S. Army Aeromedical Research Laboratory 6901 Farrel Road Fort Rucker Alabama 
      22206; National Intrepid Center of Excellence Walter Reed National Military 
      Medical Center 4860 South Palmer Road Bethesda Maryland 20889; Human Dimension 
      Division (HDD) Headquarters Army Training and Doctrine Command (HQ TRADOC) 950 
      Jefferson Ave Fort Eustis Virginia 23604.
FAU - Williams, Kathy
AU  - Williams K
AD  - National Intrepid Center of Excellence Walter Reed National Military Medical 
      Center 4860 South Palmer Road Bethesda Maryland 20889.
FAU - Emmerich, Tanja
AU  - Emmerich T
AD  - Roskamp Institute 2040 Whitfield Ave Sarasota Florida 34243.
FAU - Crynen, Gogce
AU  - Crynen G
AD  - Roskamp Institute 2040 Whitfield Ave Sarasota Florida 34243.
FAU - Ait-Ghezala, Ghania
AU  - Ait-Ghezala G
AD  - Roskamp Institute 2040 Whitfield Ave Sarasota Florida 34243.
FAU - Chaytow, Helena
AU  - Chaytow H
AD  - Roskamp Institute 2040 Whitfield Ave Sarasota Florida 34243.
FAU - Mathura, Venkat
AU  - Mathura V
AD  - Roskamp Institute 2040 Whitfield Ave Sarasota Florida 34243.
FAU - Crawford, Fiona C
AU  - Crawford FC
AD  - Roskamp Institute 2040 Whitfield Ave Sarasota Florida 34243.
FAU - Iverson, Grant L
AU  - Iverson GL
AD  - Department of Physical Medicine and Rehabilitation Harvard Medical School Boston 
      Massachusetts; Spaulding Rehabilitation Hospital Boston Massachusetts; Red Sox 
      Foundation and Massachusetts General Hospital Home Base Program Boston 
      Massachusetts; Defense and Veterans Brain Injury Center Bethesda Maryland; Center 
      for Health and Rehabilitation Department of Physical Medicine & Rehabilitation 
      Harvard Medical School 79/96 Thirteenth Street Charlestown Navy Yard Charlestown 
      Massachusetts 02129.
LA  - eng
PT  - Journal Article
DEP - 20151217
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain Concussion/*complications/psychology
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - Female
MH  - Humans
MH  - Iraq War, 2003-2011
MH  - Male
MH  - Military Personnel/psychology/statistics & numerical data
MH  - Polymorphism, Genetic/*genetics
MH  - Prospective Studies
MH  - Stress Disorders, Post-Traumatic/blood/*complications/genetics
MH  - Stress, Psychological/*complications/psychology
PMC - PMC4834940
OTO - NOTNLM
OT  - BDNF
OT  - deployment
OT  - genetics
OT  - military
OT  - posttraumatic stress disorder
OT  - psychological health
OT  - traumatic brain injury
EDAT- 2016/04/26 06:00
MHDA- 2016/04/26 06:01
PMCR- 2015/12/17
CRDT- 2016/04/26 06:00
PHST- 2015/02/25 00:00 [received]
PHST- 2015/07/22 00:00 [revised]
PHST- 2015/08/16 00:00 [accepted]
PHST- 2016/04/26 06:00 [entrez]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2016/04/26 06:01 [medline]
PHST- 2015/12/17 00:00 [pmc-release]
AID - BRB3392 [pii]
AID - 10.1002/brb3.392 [doi]
PST - epublish
SO  - Brain Behav. 2015 Dec 17;6(1):e00392. doi: 10.1002/brb3.392. eCollection 2016 
      Jan.