PMID- 27111856
OWN - NLM
STAT- MEDLINE
DCOM- 20170629
LR  - 20171202
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 46
IP  - 7
DP  - 2016 Jul
TI  - Bortezomib treatment diminishes hazelnut-induced intestinal anaphylaxis in mice.
PG  - 1727-36
LID - 10.1002/eji.201545918 [doi]
AB  - Food allergy is a common health problem and can cause anaphylaxis. Avoidance of 
      the offending food allergen is still the mainstay therapeutic approach. In this 
      study, we investigated the role of plasma cell reduction by proteasome inhibition 
      in a murine model of food allergy and examined the impact of this treatment on 
      the systemic and local immune response. For this purpose, intestinal anaphylaxis 
      was induced in BALB/c mice with the food allergen hazelnut, in conjunction with 
      different adjuvants (alum and Staphylococcal enterotoxin B SEB) and different 
      administration routes (oral and intraperitoneal). In both models, allergy 
      symptoms were observed, but the clinical severity was more pronounced in the 
      hazelnut-alum model than in the hazelnut-SEB model. Accordingly, 
      allergen-specific immunoglobulin E (IgE) against hazelnut was detectable, and 
      mast cell protease-1 in serum was increased after allergen provocation. Treatment 
      with the proteasome inhibitor bortezomib reduced plasma cells and resulted in an 
      abolishment of hazelnut allergen-specific IgE, which was associated with 
      amelioration of clinical symptoms as well as a significant decrease in both 
      CD19(+) and follicular B lymphocytes. Our data demonstrate the importance of 
      allergen-specific IgE in food allergy and point to B cells as potential 
      therapeutic targets for its treatment.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Mudnakudu Nagaraju, Kiran Kumar
AU  - Mudnakudu Nagaraju KK
AD  - Department of Dermatology und Allergology, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin, Berlin, Germany.
FAU - Babina, Magda
AU  - Babina M
AD  - Department of Dermatology und Allergology, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin, Berlin, Germany.
FAU - Weise, Christin
AU  - Weise C
AD  - Department of Dermatology und Allergology, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin, Berlin, Germany.
FAU - Kuhl, Anja
AU  - Kuhl A
AD  - Department of Medicine-I for Gastroenterology, Infectious Disease and 
      Rheumatology, Research Center ImmunoSciences, Charite - Universitatsmedizin, 
      Berlin, Germany.
FAU - Schulzke, Joerg
AU  - Schulzke J
AD  - Department of Gastroenterology, Infectious Diseases and Rheumatology, Charite - 
      Universitatsmedizin, Berlin, Germany.
FAU - Worm, Margitta
AU  - Worm M
AD  - Department of Dermatology und Allergology, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160511
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Allergens)
RN  - 0 (Proteasome Inhibitors)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 69G8BD63PP (Bortezomib)
SB  - IM
MH  - Allergens/*immunology
MH  - Anaphylaxis/diagnosis/drug therapy/*immunology
MH  - Animals
MH  - B-Lymphocytes/drug effects/immunology/metabolism
MH  - Bortezomib/administration & dosage/*pharmacology
MH  - Corylus/*adverse effects
MH  - Disease Models, Animal
MH  - Female
MH  - Food Hypersensitivity/diagnosis/drug therapy/*immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Intestines/drug effects/*immunology/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Proteasome Inhibitors/administration & dosage/pharmacology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Anaphylaxis
OT  - B cells
OT  - Food allergy
OT  - Immunoglobulin E
OT  - Proteasome inhibition
EDAT- 2016/04/26 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/04/26 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2016/04/01 00:00 [revised]
PHST- 2016/04/19 00:00 [accepted]
PHST- 2016/04/26 06:00 [entrez]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - 10.1002/eji.201545918 [doi]
PST - ppublish
SO  - Eur J Immunol. 2016 Jul;46(7):1727-36. doi: 10.1002/eji.201545918. Epub 2016 May 
      11.