PMID- 27112243
OWN - NLM
STAT- MEDLINE
DCOM- 20170222
LR  - 20170309
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 67
IP  - 4
DP  - 2016 Apr 25
TI  - [Proton Pump Inhibitor-responsive Esophageal Eosinophilia: An Overview of Cases 
      from One University Hospital Center].
PG  - 178-82
LID - 10.4166/kjg.2016.67.4.178 [doi]
AB  - BACKGROUND/AIMS: Eosinophilic esophagitis (EoE) is a chronic, 
      immune/antigen-mediated esophageal disease, with eosinophilic infiltration 
      limited to the esophagus. A minority of EoE patients respond well to proton pump 
      inhibitor (PPI) therapy alone, and that condition is labelled PPI-responsive 
      esophageal eosinophilia (PPI-REE). The prevalence of PPI-REE among EoE cases is 
      unknown. We aimed to identify clinical manifestations of PPI-REE, and the 
      proportion of PPI-REE among all EoE cases. METHODS: We reviewed pathology of the 
      4,075 patients who underwent esophageal biopsy at an institution from March 2003 
      to July 2015. EoE was diagnosed based on esophageal symptoms and eosinophilic 
      infiltration limited to the esophagus, with >/=15 eosinophils per high-power field. 
      We collected endoscopic and pathologic findings, and clinical features for these 
      patients. RESULTS: Thirteen (0.3%) patients were diagnosed with EoE. Clinical 
      manifestations were dysphagia (30.8%), foreign body sensation (23.1%), 
      regurgitation (23.1%), cough (15.4%), heartburn (15.4%), nausea (7.7%), dyspepsia 
      (7.7%). The endoscopic findings noted were polypoid lesion (23.1%), whitish 
      plaque or exudate (23.1%), linear furrow (7.7%), concentric ring (7.7%), 
      nodularity (7.7%), erosion (7.7%), and normal (30.8%). Of these patients, five 
      had a favorable course with PPI as monotherapy. CONCLUSIONS: The proportion of 
      EoE among all patients undergoing endoscopic biopsy was 0.3%. Of those, PPI-REE 
      comprised 38%. Most of the endoscopic findings were atypical or normal when 
      compared to the typical findings in EoE. In conclusion, patients who present with 
      symptoms related to esophageal dysfunction need esophageal biopsy, regardless of 
      the endoscopic findings. Moreover, patients diagnosed with EoE need to be treated 
      first with PPI alone.
FAU - Ahn, Byungkyu
AU  - Ahn B
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Lee, Dong Ho
AU  - Lee DH
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
AD  - Liver Research Institute, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Lee, Chang Min
AU  - Lee CM
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Hwang, Jae Jin
AU  - Hwang JJ
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Yoon, Hyuk
AU  - Yoon H
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Shin, Cheol Min
AU  - Shin CM
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Park, Young Soo
AU  - Park YS
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Kim, Nayoung
AU  - Kim N
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
AD  - Liver Research Institute, Seoul National University College of Medicine, Seoul, 
      Korea.
LA  - kor
PT  - Journal Article
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endoscopy, Gastrointestinal
MH  - Eosinophilic Esophagitis/*diagnosis/etiology
MH  - Esophagus/pathology
MH  - Female
MH  - Gastroesophageal Reflux/drug therapy
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Eosinophilia
OT  - Eosinophilic esophagitis
OT  - Eosinophils
OT  - Esophagus
OT  - Proton pump inhibitors
EDAT- 2016/04/27 06:00
MHDA- 2017/02/23 06:00
CRDT- 2016/04/27 06:00
PHST- 2016/04/27 06:00 [entrez]
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2017/02/23 06:00 [medline]
AID - 10.4166kjg.2016.67.4.178 [pii]
AID - 10.4166/kjg.2016.67.4.178 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2016 Apr 25;67(4):178-82. doi: 10.4166/kjg.2016.67.4.178.