PMID- 27112318
OWN - NLM
STAT- MEDLINE
DCOM- 20170404
LR  - 20170404
IS  - 2295-3337 (Electronic)
IS  - 1784-3286 (Linking)
VI  - 71
IP  - 6
DP  - 2016 Dec
TI  - Noninvasive ventilation in amyotrophic lateral sclerosis: effects on sleep 
      quality and quality of life.
PG  - 389-394
AB  - OBJECTIVES: Little is known about the effects of noninvasive ventilation (NIV) on 
      sleep quality in amyotrophic lateral sclerosis (ALS). We aim to evaluate the 
      long-term effects of NIV on sleep quality and quality of life in patients with 
      ALS. METHODS: In this prospective observational study, 13 ALS patients were 
      followed for one year after initiating NIV. We evaluated sleep quality, quality 
      of life and functional status with several questionnaires: Epworth sleepiness 
      Scale (ESS), Pittsburg sleep quality index (PSQI), Short Form 36 Health 
      Questionnaire (SF-36), McGill Quality of Life questionnaire (McGillQoL) and 
      revised Amyotrophic Lateral Sclerosis Functional Rating Scale scores (ALSFRS-R). 
      RESULTS: Median and interquartile range (IQR) at the start of NIV was 59 (53-65) 
      years. The ALSFRS-R at start was 30 (24-37) (median, IQR), with three patients 
      having severe bulbar impairment (ALSFRS-R-bulbar </= 9). The P(a)CO(2) at start of 
      NIV treatment was 48 (43-52) mmHg (median, IQR). During the one-year follow-up 
      period, a significant decrease in the ALSFRS-R was observed. The impact of NIV in 
      a short term (1 month) revealed a statistically significant decrease in ESS, 
      decrease in total PSQI and of four PSQI subscales and improvement of almost all 
      subscales of the McGill questionnaire. Long-term analyses (9 months to 1 year) 
      revealed that amelioration in ESS and total PSQI was sustained. CONCLUSION: We 
      conclude that accurately titrated NIV in ALS patients can stabilize sleep quality 
      and quality of life for at least one year, despite significant disease 
      progression.
FAU - Vandoorne, Eva
AU  - Vandoorne E
AD  - a Department of Pulmonology , University of Leuven , Leuven , Belgium.
FAU - Vrijsen, Bart
AU  - Vrijsen B
AD  - a Department of Pulmonology , University of Leuven , Leuven , Belgium.
AD  - b Leuven University Centre for Sleep/Wake Disorders, Department of Pulmonology , 
      University Hospitals Leuven , Leuven , Belgium.
FAU - Belge, Catharina
AU  - Belge C
AD  - a Department of Pulmonology , University of Leuven , Leuven , Belgium.
AD  - b Leuven University Centre for Sleep/Wake Disorders, Department of Pulmonology , 
      University Hospitals Leuven , Leuven , Belgium.
FAU - Testelmans, Dries
AU  - Testelmans D
AD  - a Department of Pulmonology , University of Leuven , Leuven , Belgium.
AD  - b Leuven University Centre for Sleep/Wake Disorders, Department of Pulmonology , 
      University Hospitals Leuven , Leuven , Belgium.
FAU - Buyse, Bertien
AU  - Buyse B
AD  - a Department of Pulmonology , University of Leuven , Leuven , Belgium.
AD  - b Leuven University Centre for Sleep/Wake Disorders, Department of Pulmonology , 
      University Hospitals Leuven , Leuven , Belgium.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160426
PL  - England
TA  - Acta Clin Belg
JT  - Acta clinica Belgica
JID - 0370306
SB  - IM
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/complications/physiopathology/*therapy
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Noninvasive Ventilation/*methods
MH  - Polysomnography
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Sleep/*physiology
MH  - Sleep Wake Disorders/etiology/*physiopathology
MH  - Surveys and Questionnaires
MH  - Time Factors
OTO - NOTNLM
OT  - Amyotrophic lateral sclerosis
OT  - Noninvasive
OT  - Quality of life
OT  - Sleep
OT  - Ventilation
EDAT- 2016/04/27 06:00
MHDA- 2017/04/05 06:00
CRDT- 2016/04/27 06:00
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2017/04/05 06:00 [medline]
PHST- 2016/04/27 06:00 [entrez]
AID - 10.1080/17843286.2016.1173941 [doi]
PST - ppublish
SO  - Acta Clin Belg. 2016 Dec;71(6):389-394. doi: 10.1080/17843286.2016.1173941. Epub 
      2016 Apr 26.