PMID- 27112685
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20170209
IS  - 0072-9752 (Print)
IS  - 0072-9752 (Linking)
VI  - 133
DP  - 2016
TI  - Autoimmune sleep disorders.
PG  - 317-26
LID - B978-0-444-63432-0.00018-9 [pii]
LID - 10.1016/B978-0-444-63432-0.00018-9 [doi]
AB  - A number of autoantibodies, some paraneoplastic, are associated with sleep 
      disorders. Morvan syndrome and limbic encephalitis, associated with voltage-gated 
      potassium channel-complex antibodies, principally against CASPR2 and LGI1, can 
      result in profound insomnia and rapid eye movement sleep behavior disorder (RBD). 
      Patients with aquaporin-4 antibodies and neuromyelitis optica may develop 
      narcolepsy in association with other evidence of hypothalamic dysfunction, 
      sometimes as the initial presentation. Central sleep apnea and central neurogenic 
      hypoventilation are found in patients with anti-N-methyl-d-aspartate receptor 
      antibody encephalitis, and obstructive sleep apnea, stridor, and hypoventilation 
      are prominent features of a novel tauopathy associated with IgLON5 antibodies. In 
      addition, paraneoplastic diseases may involve the hypothalamus and cause sleep 
      disorders, particularly narcolepsy and RBD in those with Ma1 and Ma2 antibodies. 
      Patients with antineuronal nuclear autoantibodies type 2 may develop stridor. 
      Several lines of evidence suggest that narcolepsy is an autoimmune disorder. 
      There is a strong relationship with the human leukocyte antigen (HLA) DQB1*06:02 
      haplotype and polymorphisms in the T-cell receptor alpha locus and purinergic 
      receptor P2Y11 genes. Patients with recent-onset narcolepsy may have high titers 
      of antistreptococcal or other antibodies, although none has yet been shown to be 
      disease-specific but, supporting an immune basis, recent evidence indicates that 
      narcolepsy in children can be precipitated by one type of vaccination against the 
      2009-2010 H1N1 influenza pandemic.
CI  - (c) 2016 Elsevier B.V. All rights reserved.
FAU - Silber, Michael H
AU  - Silber MH
AD  - Center for Sleep Medicine and Department of Neurology, Mayo Clinic College of 
      Medicine, Rochester, MN, USA. Electronic address: msilber@mayo.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Handb Clin Neurol
JT  - Handbook of clinical neurology
JID - 0166161
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies/immunology
MH  - Autoimmune Diseases/*complications
MH  - Humans
MH  - Sleep Wake Disorders/*complications
OTO - NOTNLM
OT  - H1N1 vaccination
OT  - HLA DQB1*06:02
OT  - IgLON5 antibodies
OT  - Ma antibodies
OT  - Morvan syndrome
OT  - N-methyl-d-aspartate receptor antibodies
OT  - REM sleep behavior disorder
OT  - aquaporin-4 antibodies
OT  - hypocretin-1
OT  - narcolepsy
OT  - voltage-gated potassium channel-complex antibodies
EDAT- 2016/04/27 06:00
MHDA- 2017/02/10 06:00
CRDT- 2016/04/27 06:00
PHST- 2016/04/27 06:00 [entrez]
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
AID - B978-0-444-63432-0.00018-9 [pii]
AID - 10.1016/B978-0-444-63432-0.00018-9 [doi]
PST - ppublish
SO  - Handb Clin Neurol. 2016;133:317-26. doi: 10.1016/B978-0-444-63432-0.00018-9.