PMID- 27113675
OWN - NLM
STAT- MEDLINE
DCOM- 20161226
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1448
DP  - 2016 May 27
TI  - Analysis of chemical warfare agents in organic liquid samples with magnetic 
      dispersive solid phase extraction and gas chromatography mass spectrometry for 
      verification of the chemical weapons convention.
PG  - 32-41
LID - S0021-9673(16)30498-8 [pii]
LID - 10.1016/j.chroma.2016.04.058 [doi]
AB  - A simple, sensitive and low temperature sample preparation method is developed 
      for detection and identification of Chemical Warfare Agents (CWAs) and scheduled 
      esters in organic liquid using magnetic dispersive solid phase extraction (MDSPE) 
      followed by gas chromatography-mass spectrometry analysis. The method utilizes 
      Iron oxide@Poly(methacrylic acid-co-ethylene glycol dimethacrylate) resin 
      (Fe2O3@Poly(MAA-co-EGDMA)) as sorbent. Variants of these sorbents were prepared 
      by precipitation polymerization of methacrylic acid-co-ethylene glycol 
      dimethacrylate (MAA-co-EGDMA) onto Fe2O3 nanoparticles. Fe2O3@poly(MAA-co-EGDMA) 
      with 20% MAA showed highest recovery of analytes. Extractions were performed with 
      magnetic microspheres by MDSPE. Parameters affecting the extraction efficiency 
      were studied and optimized. Under the optimized conditions, method showed 
      linearity in the range of 0.1-3.0mugmL(-1) (r(2)=0.9966-0.9987). The repeatability 
      and reproducibility (relative standard deviations (RSDs) %) were in the range of 
      4.5-7.6% and 3.4-6.2% respectively for organophosphorous esters in dodecane. 
      Limits of detection (S/N=3/1) and limit of quantification (S/N=10/1) were found 
      to be in the range of 0.05-0.1mugmL(-1) and 0.1-0.12mugmL(-1) respectively in SIM 
      mode for selected analytes. The method was successfully validated and applied to 
      the extraction and identification of targeted analytes from three different 
      organic liquids i.e. n-hexane, dodecane and silicon oil. Recoveries ranged from 
      58.7 to 97.3% and 53.8 to 95.5% at 3mugmL(-1) and 1mugmL(-1) spiking 
      concentrations. Detection of diethyl methylphosphonate (DEMP) and O-Ethyl 
      S-2-diisopropylaminoethyl methylphosphonothiolate (VX) in samples provided by the 
      Organization for Prohibition of Chemical Weapons Proficiency Test (OPCW-PT) 
      proved the utility of the developed method for the off-site analysis of CWC 
      relevant chemicals.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Singh, Varoon
AU  - Singh V
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India.
FAU - Purohit, Ajay Kumar
AU  - Purohit AK
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India.
FAU - Chinthakindi, Sridhar
AU  - Chinthakindi S
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India.
FAU - Goud, Raghavender D
AU  - Goud RD
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India.
FAU - Tak, Vijay
AU  - Tak V
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India.
FAU - Pardasani, Deepak
AU  - Pardasani D
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India.
FAU - Shrivastava, Anchal Roy
AU  - Shrivastava AR
AD  - Electron Microscopy Division, Defence Research and Development Establishment, 
      Jhansi road, Gwalior 474002, India.
FAU - Dubey, Devendra Kumar
AU  - Dubey DK
AD  - Vertox Laboratory, Defence Research and Development Establishment, Jhansi road, 
      Gwalior 474002, India. Electronic address: dkdubey@rediffmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160420
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Alkanes)
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Ferric Compounds)
RN  - 0 (Hexanes)
RN  - 0 (Organophosphonates)
RN  - 0 (Organothiophosphorus Compounds)
RN  - 0 (Polymethacrylic Acids)
RN  - 0 (Silicone Oils)
RN  - 0 (poly((ethylene glycol dimethacrylate)-co-(methacrylic acid)))
RN  - 11A386X1QH (n-dodecane)
RN  - 1K09F3G675 (ferric oxide)
RN  - 2DDG612ED8 (n-hexane)
SB  - IM
MH  - Alkanes/*chemistry
MH  - Chemical Warfare Agents/*analysis
MH  - Ferric Compounds/chemistry
MH  - Gas Chromatography-Mass Spectrometry/instrumentation/methods
MH  - Hexanes/*chemistry
MH  - Magnetics
MH  - Organophosphonates/*analysis
MH  - Organothiophosphorus Compounds/*analysis
MH  - Polymethacrylic Acids/chemistry
MH  - Reproducibility of Results
MH  - Silicone Oils/*chemistry
MH  - Solid Phase Extraction/methods
OTO - NOTNLM
OT  - Chemical warfare agents
OT  - Chemical weapons convention
OT  - GC-MS
OT  - Magnetic dispersive solid phase extraction
OT  - Magnetic nanoparticles
OT  - Sample preparation
EDAT- 2016/04/27 06:00
MHDA- 2016/12/27 06:00
CRDT- 2016/04/27 06:00
PHST- 2016/02/10 00:00 [received]
PHST- 2016/04/05 00:00 [revised]
PHST- 2016/04/19 00:00 [accepted]
PHST- 2016/04/27 06:00 [entrez]
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2016/12/27 06:00 [medline]
AID - S0021-9673(16)30498-8 [pii]
AID - 10.1016/j.chroma.2016.04.058 [doi]
PST - ppublish
SO  - J Chromatogr A. 2016 May 27;1448:32-41. doi: 10.1016/j.chroma.2016.04.058. Epub 
      2016 Apr 20.