PMID- 27114422
OWN - NLM
STAT- MEDLINE
DCOM- 20170727
LR  - 20181113
IS  - 2005-1212 (Electronic)
IS  - 1976-2283 (Print)
IS  - 1976-2283 (Linking)
VI  - 10
IP  - 5
DP  - 2016 Sep 15
TI  - Sensitization to and Challenge with Gliadin Induce Pancreatitis and 
      Extrapancreatic Inflammation in HLA-DQ8 Mice: An Animal Model of Type 1 
      Autoimmune Pancreatitis.
PG  - 842-50
LID - 10.5009/gnl15484 [doi]
AB  - BACKGROUND/AIMS: The aim of this study was to establish a pathogenetic mechanism 
      of pancreatitis in celiac disease and IgG4-related disease using gluten-sensitive 
      human leukocyte antigen (HLA)-DQ8 transgenic mice. METHODS: Transgenic mice 
      expressing HLA-DQ8 genes were utilized. Control mice were not sensitized but were 
      fed gliadin-free rice cereal. Experimental groups consisted of gliadin-sensitized 
      and gliadin-challenged mice; nonsensitized mice with cerulein hyperstimulation; 
      and gliadin-sensitized and gliadinchallenged mice with cerulein hyperstimulation. 
      RESULTS: Gliadin-sensitized and gliadin-challenged mice with cerulein 
      hyperstimulation showed significant inflammatory cell infiltrates, fibrosis and 
      acinar atrophy compared with the control mice and the other experimental groups. 
      The immunohistochemical analysis showed greater IgG1-positive plasma cells in the 
      inflammatory infiltrates of gliadin-sensitized and gliadin-challenged mice with 
      cerulein hyperstimulation compared with the control mice and the other 
      experimental groups. Gliadin-sensitized and gliadin-challenged mice with cerulein 
      hyperstimulation or gliadin-sensitized and gliadinchallenged mice showed 
      IgG1-stained inflammatory cell infiltrates in the extrapancreatic organs, 
      including the bile ducts, salivary glands, kidneys, and lungs. CONCLUSIONS: 
      Gliadinsensitization and cerulein hyperstimulation of gluten-sensitive HLA-DQ8 
      transgenic mice resulted in pancreatitis and extrapancreatic inflammation. This 
      animal model suggests that chronic gliadin ingestion in a susceptible individual 
      with the HLA-DQ8 molecule may be associated with pancreatitis and extrapancreatic 
      inflammation.
FAU - Moon, Sung-Hoon
AU  - Moon SH
AD  - Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym 
      University College of Medicine, Anyang, Korea.
FAU - Kim, Jihun
AU  - Kim J
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Kim, Mi-Young
AU  - Kim MY
AD  - Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 
      Seongnam, Korea.
FAU - Park, Do Hyun
AU  - Park do H
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Song, Tae Jun
AU  - Song TJ
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Kim, Sun A
AU  - Kim SA
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Lee, Sang Soo
AU  - Lee SS
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Seo, Dong Wan
AU  - Seo DW
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Lee, Sung Koo
AU  - Lee SK
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Kim, Myung-Hwan
AU  - Kim MH
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Gut Liver
JT  - Gut and liver
JID - 101316452
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (Immunoglobulin G)
RN  - 888Y08971B (Ceruletide)
RN  - 9007-90-3 (Gliadin)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*immunology
MH  - Ceruletide/immunology
MH  - Disease Models, Animal
MH  - Gliadin/*immunology
MH  - HLA-DQ Antigens/*immunology
MH  - *Hypersensitivity
MH  - Immunoglobulin G/blood
MH  - Inflammation/immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Pancreatitis/chemically induced/*immunology
PMC - PMC5003210
OTO - NOTNLM
OT  - Autoimmune diseases
OT  - Celiac disease
OT  - Pancreatitis
EDAT- 2016/04/27 06:00
MHDA- 2017/07/28 06:00
PMCR- 2016/09/01
CRDT- 2016/04/27 06:00
PHST- 2015/09/24 00:00 [received]
PHST- 2015/10/27 00:00 [revised]
PHST- 2015/11/10 00:00 [accepted]
PHST- 2016/04/27 06:00 [entrez]
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2017/07/28 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - gnl15484 [pii]
AID - gnl-10-842 [pii]
AID - 10.5009/gnl15484 [doi]
PST - ppublish
SO  - Gut Liver. 2016 Sep 15;10(5):842-50. doi: 10.5009/gnl15484.