PMID- 27115705
OWN - NLM
STAT- MEDLINE
DCOM- 20170323
LR  - 20220321
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Print)
IS  - 0944-1344 (Linking)
VI  - 23
IP  - 15
DP  - 2016 Aug
TI  - Quantifying the impact of PM2.5 and associated heavy metals on respiratory health 
      of children near metallurgical facilities.
PG  - 15395-406
LID - 10.1007/s11356-016-6734-x [doi]
AB  - The aim of this study was to link the concentrations of particulate matter with 
      an aerodynamic diameter below 2.5 mum (PM2.5) and associated heavy metals with 
      occurrence of wheezing and hospitalizations due to wheezing in 111 children who 
      live near metallurgical plants in Targoviste City, Romania. A group of 72 
      children with high levels of immunoglobulin E (IgE) and eosinophils, as well as 
      frequent wheezing episodes, was geolocated on digital thematic maps. Monitoring 
      campaigns and medical assessments were performed over two consecutive years 
      (2013-2014). The multiannual average concentrations of PM2.5 ranged from 4.6 to 
      22.5 mug m(-3), up to a maximum value of 102 mug m(-3). Significant correlations 
      (p < 0.01) were observed between the locations of the children with respiratory 
      issues and the PM2.5 multiannual average (r = 0.985) and PM2.5 maximum 
      (r = 0.813). Fe, Ni, Cd, and Cr were the main marker elements of the emissions 
      from steel production and metal-working facilities in the Targoviste area. The 
      results support the hypothesis that increased PM2.5 levels directly influence 
      wheezing symptom and asthma attacks in the analyzed group. IgE, eosinophils, and 
      wheezing episodes may be considered key indicators with which to evaluate the 
      adverse effects of PM2.5 air pollution on children's health.
FAU - Dunea, Daniel
AU  - Dunea D
AD  - Valahia University of Targoviste, Aleea Sinaia no. 13, RO-130004, Targoviste, 
      Romania. ddunea@yahoo.com.
FAU - Iordache, Stefania
AU  - Iordache S
AD  - Valahia University of Targoviste, Aleea Sinaia no. 13, RO-130004, Targoviste, 
      Romania.
FAU - Liu, Hai-Ying
AU  - Liu HY
AD  - Norwegian Institute for Air Research - NILU, Instituttveien 18, PO Box 100, 
      NO-2027, Kjeller, Norway.
FAU - Bohler, Trond
AU  - Bohler T
AD  - Norwegian Institute for Air Research - NILU, Instituttveien 18, PO Box 100, 
      NO-2027, Kjeller, Norway.
FAU - Pohoata, Alin
AU  - Pohoata A
AD  - Valahia University of Targoviste, Aleea Sinaia no. 13, RO-130004, Targoviste, 
      Romania.
FAU - Radulescu, Cristiana
AU  - Radulescu C
AD  - Valahia University of Targoviste, Aleea Sinaia no. 13, RO-130004, Targoviste, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20160426
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Air Pollutants)
RN  - 0 (Metals, Heavy)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Air Pollutants/*analysis
MH  - Asthma/chemically induced/*epidemiology
MH  - Child
MH  - Environmental Monitoring/*methods
MH  - Humans
MH  - *Metallurgy
MH  - Metals, Heavy/*analysis
MH  - Particle Size
MH  - Particulate Matter/*analysis
MH  - Respiratory Sounds/drug effects
MH  - Romania
PMC - PMC4956698
OTO - NOTNLM
OT  - Environmental mapping system
OT  - Eosinophil count
OT  - Fine particulates
OT  - Immunoglobulin E
OT  - Wheezing
EDAT- 2016/04/27 06:00
MHDA- 2017/03/24 06:00
PMCR- 2016/04/26
CRDT- 2016/04/27 06:00
PHST- 2015/11/17 00:00 [received]
PHST- 2016/04/20 00:00 [accepted]
PHST- 2016/04/27 06:00 [entrez]
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2017/03/24 06:00 [medline]
PHST- 2016/04/26 00:00 [pmc-release]
AID - 10.1007/s11356-016-6734-x [pii]
AID - 6734 [pii]
AID - 10.1007/s11356-016-6734-x [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2016 Aug;23(15):15395-406. doi: 
      10.1007/s11356-016-6734-x. Epub 2016 Apr 26.