PMID- 27116638
OWN - NLM
STAT- MEDLINE
DCOM- 20180216
LR  - 20180216
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 7
IP  - 5
DP  - 2016 May 18
TI  - Niacin and olive oil promote skewing to the M2 phenotype in bone marrow-derived 
      macrophages of mice with metabolic syndrome.
PG  - 2233-8
LID - 10.1039/c6fo00381h [doi]
AB  - Metabolic syndrome (MetS) is associated with obesity, dyslipemia, type 2 diabetes 
      and chronic low-grade inflammation. The aim of this study was to determine the 
      role of high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs 
      (HFLCD-MUFAs) or MUFAs plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on 
      polarisation and inflammatory potential in bone marrow-derived macrophages 
      (BMDMs) from niacin (NA)-treated Lep(ob/ob)LDLR(-/-) mice. Animals fed with 
      HFLCD-SFAs had increased weight and serum triglycerides, and their BMDMs 
      accumulated triglycerides over the animals fed with HFLCD-MUFAs or -PUFAs. 
      Furthermore, BMDMs from animals fed with HFLCD-SFAs were polarised towards the M1 
      phenotype with functional competence to produce pro-inflammatory cytokines, 
      whereas BMDMs from animals fed with HFLCD-MUFAs or -PUFAs were skewed to the 
      anti-inflammatory M2 phenotype. These findings open opportunities for developing 
      novel nutritional strategies with olive oil as the most important dietary source 
      of MUFAs (notably oleic acid) to prevent development and progression of metabolic 
      complications in the NA-treated MetS.
FAU - Montserrat-de la Paz, Sergio
AU  - Montserrat-de la Paz S
AD  - Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, 
      Ctra. de Utrera Km. 1, 41013 Seville, Spain. delapaz@us.es muriana@ig.csic.es.
FAU - Naranjo, Maria C
AU  - Naranjo MC
FAU - Lopez, Sergio
AU  - Lopez S
FAU - Abia, Rocio
AU  - Abia R
FAU - Muriana, Francisco J G
AU  - Muriana FJ
FAU - Bermudez, Beatriz
AU  - Bermudez B
LA  - eng
PT  - Journal Article
DEP - 20160426
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Cytokines)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Olive Oil)
RN  - 0 (Triglycerides)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 2679MF687A (Niacin)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Cholesterol/blood
MH  - Cytokines/metabolism
MH  - Diet
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Docosahexaenoic Acids/administration & dosage
MH  - Eicosapentaenoic Acid/administration & dosage
MH  - Fatty Acids, Monounsaturated/administration & dosage
MH  - Fatty Acids, Omega-3/administration & dosage
MH  - Fatty Acids, Unsaturated/administration & dosage
MH  - Inflammation
MH  - Macrophages/*metabolism
MH  - Male
MH  - Metabolic Syndrome/diet therapy/*metabolism/prevention & control
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Niacin/*administration & dosage
MH  - Oleic Acid/pharmacology
MH  - Olive Oil/*administration & dosage
MH  - *Phenotype
MH  - Triglycerides/blood
EDAT- 2016/04/27 06:00
MHDA- 2018/02/17 06:00
CRDT- 2016/04/27 06:00
PHST- 2016/04/27 06:00 [entrez]
PHST- 2016/04/27 06:00 [pubmed]
PHST- 2018/02/17 06:00 [medline]
AID - 10.1039/c6fo00381h [doi]
PST - ppublish
SO  - Food Funct. 2016 May 18;7(5):2233-8. doi: 10.1039/c6fo00381h. Epub 2016 Apr 26.