PMID- 27118529
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20180110
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 30
IP  - 7
DP  - 2016 Jul
TI  - Treating posttraumatic stress disorder with MDMA-assisted psychotherapy: A 
      preliminary meta-analysis and comparison to prolonged exposure therapy.
PG  - 595-600
LID - 10.1177/0269881116642542 [doi]
AB  - Since the wars in Iraq and Afghanistan, posttraumatic stress disorder (PTSD) has 
      become a major area of research and development. The most widely accepted 
      treatment for PTSD is prolonged exposure (PE) therapy, but for many patients it 
      is intolerable or ineffective. +/-3,4-methylenedioxymethamphetamine (MDMA)-assisted 
      psychotherapy (MDMA-AP) has recently re-emerged as a new treatment option, with 
      two clinical trials having been published and both producing promising results. 
      However, these results have yet to be compared to existing treatments. The 
      present paper seeks to bridge this gap in the literature. Often the statistical 
      significance of clinical trials is overemphasized, while the magnitude of the 
      treatment effects is overlooked. The current meta-analysis aims to provide a 
      comparison of the cumulative effect size of the MDMA-AP studies with those of PE. 
      Effect sizes were calculated for primary and secondary outcome measures in the 
      MDMA-AP clinical trials and compared to those of a meta-analysis including 
      several PE clinical trials. It was found that MDMA-AP had larger effect sizes in 
      both clinician-observed outcomes than PE did (Hedges' g=1.17 vs. g=1.08, 
      respectively) and patient self-report outcomes (Hedges' g=0.87 vs. g=0.77, 
      respectively). The dropout rates of PE and MDMA-AP were also compared, revealing 
      that MDMA-AP had a considerably lower percentage of patients dropping out than PE 
      did. These results suggest that MDMA-AP offers a promising treatment for PTSD.
CI  - (c) The Author(s) 2016.
FAU - Amoroso, Timothy
AU  - Amoroso T
AD  - Department of Psychology, University of New Hampshire, Durham, NH, USA 
      timamoroso@gmail.com.
FAU - Workman, Michael
AU  - Workman M
AD  - Department of Biological Sciences, University of New Hampshire, Durham, NH, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20160426
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Implosive Therapy/methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*therapeutic use
MH  - Psychotherapy/methods
MH  - Stress Disorders, Post-Traumatic/*drug therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - MDMA
OT  - PTSD
OT  - meta-analysis
OT  - prolonged exposure therapy
OT  - psychotherapy
EDAT- 2016/04/28 06:00
MHDA- 2017/12/28 06:00
CRDT- 2016/04/28 06:00
PHST- 2016/04/28 06:00 [entrez]
PHST- 2016/04/28 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
AID - 0269881116642542 [pii]
AID - 10.1177/0269881116642542 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2016 Jul;30(7):595-600. doi: 10.1177/0269881116642542. Epub 
      2016 Apr 26.