PMID- 27119981
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20171120
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 62
DP  - 2016 Sep
TI  - Immune responses to modified live virus vaccines developed from classical or 
      highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV 
      strain.
PG  - 1-7
LID - S0145-305X(16)30142-2 [pii]
LID - 10.1016/j.dci.2016.04.019 [doi]
AB  - Modified live virus vaccines (MLVs) are used on swine farms to control porcine 
      reproductive and respiratory syndrome virus (PRRSV). MLVs from classical PRRSV 
      (C-PRRSV) provide some protection against emergent highly pathogenic PRRSV 
      (HP-PRRSV). This study characterized the protective efficacy and immune response 
      to MLVs from C-PRRSV (CH-1R) or HP-PRRSV (HuN4-F112) in a challenge using 
      HP-PRRSV (HuN4). The outcomes were clinical signs of disease, pathological 
      changes in the thymus and lungs, viremia, and humoral and cellular immune 
      responses. CH-1R provided some protection against challenge with HuN4, while 
      HuN4-F112 was protective in the HuN4 challenge. Compared to unvaccinated piglets, 
      the vaccinated piglets had milder symptoms and fewer pathological changes in the 
      lung and thymus. Piglets vaccinated with HuN4-F112 had higher antibody titers and 
      lower viral loads than piglets vaccinated with CH-1R post challenge. The 
      differences in outcome between the MLVs suggested that underlying differences in 
      the immune responses might warrant further study.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Wang, Gang
AU  - Wang G
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Yu, Ying
AU  - Yu Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China; 
      Department of Preventive Veterinary Medicine, College of Veterinary Medicine, 
      Northwest A&F University, Yangling, Shaanxi, 712100, PR China.
FAU - Zhang, Chong
AU  - Zhang C
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China; 
      Jilin Agricultural University, Changchun, 130118, PR China.
FAU - Tu, Yabin
AU  - Tu Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Tong, Jie
AU  - Tong J
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Liu, Yonggang
AU  - Liu Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Chang, Yafei
AU  - Chang Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Jiang, Chenggang
AU  - Jiang C
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Wang, Shujie
AU  - Wang S
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China.
FAU - Zhou, En-Min
AU  - Zhou EM
AD  - Department of Preventive Veterinary Medicine, College of Veterinary Medicine, 
      Northwest A&F University, Yangling, Shaanxi, 712100, PR China. Electronic 
      address: zhouem@nwsuaf.edu.cn.
FAU - Cai, Xuehui
AU  - Cai X
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, PR China. 
      Electronic address: cai139@hvri.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160424
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Immunity, Cellular
MH  - Immunity, Humoral
MH  - Leukocytes, Mononuclear/*immunology/virology
MH  - Lung/*immunology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/pathogenicity/*physiology
MH  - Swine/*immunology
MH  - Thymus Gland/*immunology/virology
MH  - Vaccination
MH  - Viral Load
MH  - Viral Vaccines/*immunology
MH  - Virulence
OTO - NOTNLM
OT  - Highly pathogenic PRRSV
OT  - Immune responses
OT  - PRRSV vaccine
EDAT- 2016/04/28 06:00
MHDA- 2017/11/03 06:00
CRDT- 2016/04/28 06:00
PHST- 2016/01/28 00:00 [received]
PHST- 2016/04/22 00:00 [revised]
PHST- 2016/04/22 00:00 [accepted]
PHST- 2016/04/28 06:00 [entrez]
PHST- 2016/04/28 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
AID - S0145-305X(16)30142-2 [pii]
AID - 10.1016/j.dci.2016.04.019 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2016 Sep;62:1-7. doi: 10.1016/j.dci.2016.04.019. Epub 2016 Apr 
      24.