PMID- 27120173
OWN - NLM
STAT- MEDLINE
DCOM- 20170518
LR  - 20181113
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 32
IP  - 1
DP  - 2017 Jan
TI  - Outcomes of plasma exchange for severe dilated cardiomyopathy in children.
PG  - 61-67
LID - 10.1007/s00380-016-0830-1 [doi]
AB  - Antimyocardial autoantibodies are a cause of dilated cardiomyopathy (DCM). 
      Immunoabsorption therapy for eliminating autoantibodies can improve cardiac 
      function in adult DCM. The purpose of this study was to investigate the 
      indication and efficacy of plasma exchange in children with DCM and their 
      outcomes. We performed a single-center, retrospective study in children with DCM 
      who had received plasma exchange (PE). Six patients in various degrees of heart 
      failure (three patients in acute exacerbation phase, one patient in early phase, 
      and two patients in chronic phase) received PE. The effects of first PE were that 
      the left ventricular ejection fraction (LVEF) and New York Heart Association 
      (NYHA) functional class were transiently increased in five of six patients (83 %) 
      and in four of five patients (80 %), respectively. The median duration of 
      improved cardiac function after first PE was 8 months. PE was performed a total 
      of two times in two patients and three times in one patient. The effect of 
      repeated PE was attenuated when compared with first PE. Improved LVEF and NYHA 
      functional class were observed in two of four courses (50 %) and in one of four 
      courses (25 %), respectively. The median duration of improved cardiac function 
      was 1 month. PE can transiently improve cardiac function and clinical symptoms of 
      DCM in children. PE may be an additional therapeutic option in children with 
      refractory DCM. However, PE should only be considered as a bridge to ventricular 
      assist device implantation or heart transplantation.
FAU - Koizumi, Keiichi
AU  - Koizumi K
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan. kkeiichi@yamanashi.ac.jp.
FAU - Hoshiai, Minako
AU  - Hoshiai M
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
FAU - Toda, Takako
AU  - Toda T
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
FAU - Katsumata, Nobuyuki
AU  - Katsumata N
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
FAU - Kise, Hiroaki
AU  - Kise H
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
FAU - Hasebe, Yohei
AU  - Hasebe Y
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
FAU - Kouno, Yousuke
AU  - Kouno Y
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
FAU - Kaga, Shigeaki
AU  - Kaga S
AD  - Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, 
      Japan.
FAU - Suzuki, Shoji
AU  - Suzuki S
AD  - Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, 
      Japan.
FAU - Sugita, Kanji
AU  - Sugita K
AD  - Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 
      Shimokato, Chuo, Yamanashi, 409-3848, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160427
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
EIN - Heart Vessels. 2018 Apr 18;:. PMID: 29671045
MH  - Cardiomyopathy, Dilated/*complications/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Infant
MH  - Japan
MH  - Male
MH  - Plasma Exchange/*methods
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Apheresis
OT  - Children
OT  - Dilated cardiomyopathy
OT  - Outcome
OT  - Plasma exchange
EDAT- 2016/04/28 06:00
MHDA- 2017/05/19 06:00
CRDT- 2016/04/28 06:00
PHST- 2015/11/07 00:00 [received]
PHST- 2016/03/25 00:00 [accepted]
PHST- 2016/04/28 06:00 [pubmed]
PHST- 2017/05/19 06:00 [medline]
PHST- 2016/04/28 06:00 [entrez]
AID - 10.1007/s00380-016-0830-1 [pii]
AID - 10.1007/s00380-016-0830-1 [doi]
PST - ppublish
SO  - Heart Vessels. 2017 Jan;32(1):61-67. doi: 10.1007/s00380-016-0830-1. Epub 2016 
      Apr 27.