PMID- 27120489
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20181202
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 32
IP  - 3
DP  - 2017 Mar
TI  - Long-term effects of in utero and lactational exposure to butyl paraben in female 
      rats.
PG  - 776-788
LID - 10.1002/tox.22277 [doi]
AB  - Parabens are used as preservatives in cosmetic, pharmaceutical, and food 
      industries, and are frequently detected as contaminants in human fluids and 
      tissues. The endocrine disrupting effects of parabens in female rodents include 
      uterotrophic response, steroidogenesis impairment, and ovarian disturbances. The 
      objective of this study was to determine the effects of maternal butyl paraben 
      (BP) exposure on female sexual development. Pregnant Wistar rats were treated 
      subcutaneously with either corn oil or BP at doses of 10, 100, or 200 mg/kg, from 
      gestational day (GD) 12 until GD 20 for female foetal gonad evaluation, and from 
      GD 12 until the end of lactation to evaluate sexual parameters on the female 
      offspring. Immature female rats were also used in the uterotrophic assay to 
      evaluate the possible estrogenic action of parabens. Our results revealed that, 
      in this experimental protocol, BP did not show estrogenic activity at the doses 
      used and did not impair sexual development and fertility capacity in the female 
      rats, but impaired sexual behavior. We conclude that brain sexual development may 
      be more sensitive to BP effects and we speculate that doses higher than 100 mg/kg 
      (the male lowest observed adverse effect level (LOAEL) for rodent reproductive 
      parameters) would be necessary to promote damages in the female reproduction, 
      regarding the same protocol of exposure. (c) 2016 Wiley Periodicals, Inc. Environ 
      Toxicol 32: 776-788, 2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Guerra, Marina Trevizan
AU  - Guerra MT
AD  - Laboratory of Reproductive and Developmental Toxicology, Department of 
      Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito de 
      Rubiao Jr s/n, 18618-970 Botucatu, Sao Paulo, Brazil.
FAU - Sanabria, Marciana
AU  - Sanabria M
AD  - Laboratory of Reproductive and Developmental Toxicology, Department of 
      Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito de 
      Rubiao Jr s/n, 18618-970 Botucatu, Sao Paulo, Brazil.
FAU - Cagliarani, Stephannie Vieira
AU  - Cagliarani SV
AD  - Laboratory of Reproductive and Developmental Toxicology, Department of 
      Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito de 
      Rubiao Jr s/n, 18618-970 Botucatu, Sao Paulo, Brazil.
FAU - Leite, Gabriel Adan Araujo
AU  - Leite GA
AD  - Laboratory of Reproductive and Developmental Toxicology, Department of 
      Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito de 
      Rubiao Jr s/n, 18618-970 Botucatu, Sao Paulo, Brazil.
FAU - Borges, Cibele Dos Santos
AU  - Borges CD
AD  - Laboratory of Reproductive and Developmental Toxicology, Department of 
      Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito de 
      Rubiao Jr s/n, 18618-970 Botucatu, Sao Paulo, Brazil.
FAU - De Grava Kempinas, Wilma
AU  - De Grava Kempinas W
AD  - Laboratory of Reproductive and Developmental Toxicology, Department of 
      Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito de 
      Rubiao Jr s/n, 18618-970 Botucatu, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160427
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Hormones)
RN  - 0 (Parabens)
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*toxicity
MH  - Estrus/drug effects
MH  - Female
MH  - Fertility/*drug effects
MH  - Hormones/blood
MH  - Humans
MH  - Lactation
MH  - Male
MH  - Maternal Exposure/adverse effects
MH  - Organ Size/drug effects
MH  - Ovary/drug effects/pathology
MH  - Parabens/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Reproduction/*drug effects
MH  - Sexual Behavior, Animal/drug effects
OTO - NOTNLM
OT  - endocrine disrupting chemicals
OT  - female reproduction
OT  - paraben
OT  - uterotrophic assay
EDAT- 2016/04/28 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/04/28 06:00
PHST- 2015/12/20 00:00 [received]
PHST- 2016/04/05 00:00 [revised]
PHST- 2016/04/07 00:00 [accepted]
PHST- 2016/04/28 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2016/04/28 06:00 [entrez]
AID - 10.1002/tox.22277 [doi]
PST - ppublish
SO  - Environ Toxicol. 2017 Mar;32(3):776-788. doi: 10.1002/tox.22277. Epub 2016 Apr 
      27.