PMID- 27121795
OWN - NLM
STAT- MEDLINE
DCOM- 20180119
LR  - 20210109
IS  - 1557-0657 (Electronic)
IS  - 1049-8931 (Print)
IS  - 1049-8931 (Linking)
VI  - 25
IP  - 4
DP  - 2016 Dec
TI  - Meta-analysis of population-based studies comparing risk of cerebrovascular 
      accident associated with first- and second-generation antipsychotic prescribing 
      in dementia.
PG  - 289-298
LID - 10.1002/mpr.1509 [doi]
AB  - BACKGROUND: Second-generation antipsychotics (SGAs) are often prescribed in the 
      treatment of Behavioral and Psychological Symptoms of Dementia (BPSD), however, 
      their use has been discouraged in light of clinical trials suggesting that they 
      cause an increased risk of cerebrovascular accidents (CVAs). OBJECTIVE: Aim of 
      the study was to assess relative risk of CVA in dementia patients prescribed SGA 
      rather than first-generation antipsychotics (FGAs), through meta-analysis of 
      population-based studies. METHODS: A literature search was conducted using 
      several relevant databases. Five studies were included in the review and data 
      were pooled to conduct meta-analysis using the inverse variance method. RESULTS: 
      A total of 79,910 patients were treated with SGAs and 1287 cases of CVA were 
      reported. Of 48,135 patients treated with FGAs, a total of 511 cases of CVA were 
      reported. The relative risk of CVA was 1.02 (95% CI 0.56-1.84) for the SGA group. 
      There was no significant difference in the risk of stroke (p = 0.96) between 
      groups, but significant heterogeneity was found among the results of included 
      studies (p < 0.001). CONCLUSION: Meta-analysis of population-based data suggested 
      that the use of SGAs as opposed to FGAs to control BPSD is not associated with 
      significantly increased risk of CVA. Copyright (c) 2016 John Wiley & Sons, Ltd.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Rao, Ahsan
AU  - Rao A
AD  - Department of Surgery and Cancer, Faculty of Medicine, St Mary's Hospital, 
      Imperial College London, London, UK.
FAU - Suliman, Amna
AU  - Suliman A
AD  - Department of Surgery and Cancer, Faculty of Medicine, St Mary's Hospital, 
      Imperial College London, London, UK.
FAU - Story, Giles
AU  - Story G
AD  - Centre for Health Policy, Institute for Global Health Innovation, St Mary's 
      Hospital, Imperial College London, London, UK.
FAU - Vuik, Sabine
AU  - Vuik S
AD  - Centre for Health Policy, Institute for Global Health Innovation, St Mary's 
      Hospital, Imperial College London, London, UK.
FAU - Aylin, Paul
AU  - Aylin P
AD  - School of Public Health, Faculty of Medicine, Dr Foster Unit, London, UK.
FAU - Darzi, Ara
AU  - Darzi A
AD  - Department of Surgery and Cancer, Faculty of Medicine, St Mary's Hospital, 
      Imperial College London, London, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160427
PL  - United States
TA  - Int J Methods Psychiatr Res
JT  - International journal of methods in psychiatric research
JID - 9111433
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antipsychotic Agents/*adverse effects
MH  - Dementia/*drug therapy/epidemiology
MH  - Humans
MH  - Stroke/*chemically induced/epidemiology
PMC - PMC6860234
OTO - NOTNLM
OT  - antipsychotics
OT  - dementia
OT  - epidemiology
EDAT- 2016/04/29 06:00
MHDA- 2018/01/20 06:00
PMCR- 2016/04/27
CRDT- 2016/04/29 06:00
PHST- 2015/08/06 00:00 [received]
PHST- 2016/02/03 00:00 [revised]
PHST- 2016/02/05 00:00 [accepted]
PHST- 2016/04/29 06:00 [pubmed]
PHST- 2018/01/20 06:00 [medline]
PHST- 2016/04/29 06:00 [entrez]
PHST- 2016/04/27 00:00 [pmc-release]
AID - MPR1509 [pii]
AID - 10.1002/mpr.1509 [doi]
PST - ppublish
SO  - Int J Methods Psychiatr Res. 2016 Dec;25(4):289-298. doi: 10.1002/mpr.1509. Epub 
      2016 Apr 27.