PMID- 27123008
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160428
LR  - 20201001
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2016
DP  - 2016
TI  - Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization.
PG  - 7131359
LID - 10.1155/2016/7131359 [doi]
LID - 7131359
AB  - Hematopoietic stem cell transplant (HSCT) using mobilized peripheral blood 
      hematopoietic stem cells (HSPCs) is the only curative strategy for many patients 
      suffering from hematological malignancies. HSPC collection protocols rely on 
      pharmacological agents to mobilize HSPCs to peripheral blood. Limitations 
      including variable donor responses and long dosing protocols merit further 
      investigations into adjuvant therapies to enhance the efficiency of HSPCs 
      collection. Exercise, a safe and feasible intervention in patients undergoing 
      HSCT, has been previously shown to robustly stimulate HSPC mobilization from the 
      bone marrow. Exercise-induced HSPC mobilization is transient limiting its current 
      clinical potential. Thus, a deeper investigation of the mechanisms responsible 
      for exercise-induced HSPC mobilization and the factors responsible for removal of 
      HSPCs from circulation following exercise is warranted. The present review will 
      describe current research on exercise and HSPC mobilization, outline the 
      potential mechanisms responsible for exercise-induced HSPC mobilization, and 
      highlight potential sites for HSPC homing following exercise. We also outline 
      current barriers to the implementation of exercise as an adjuvant therapy for 
      HSPC mobilization and suggest potential strategies to overcome these barriers.
FAU - Emmons, Russell
AU  - Emmons R
AD  - Department of Kinesiology and Community Health, University of Illinois at 
      Urbana-Champaign, Urbana, IL 61801, USA.
FAU - Niemiro, Grace M
AU  - Niemiro GM
AD  - Department of Kinesiology and Community Health, University of Illinois at 
      Urbana-Champaign, Urbana, IL 61801, USA.
FAU - De Lisio, Michael
AU  - De Lisio M
AD  - Department of Kinesiology and Community Health, University of Illinois at 
      Urbana-Champaign, Urbana, IL 61801, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160331
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC4830735
EDAT- 2016/04/29 06:00
MHDA- 2016/04/29 06:01
PMCR- 2016/03/31
CRDT- 2016/04/29 06:00
PHST- 2015/11/25 00:00 [received]
PHST- 2016/02/03 00:00 [revised]
PHST- 2016/02/07 00:00 [accepted]
PHST- 2016/04/29 06:00 [entrez]
PHST- 2016/04/29 06:00 [pubmed]
PHST- 2016/04/29 06:01 [medline]
PHST- 2016/03/31 00:00 [pmc-release]
AID - 10.1155/2016/7131359 [doi]
PST - ppublish
SO  - Stem Cells Int. 2016;2016:7131359. doi: 10.1155/2016/7131359. Epub 2016 Mar 31.