PMID- 27123461
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 
      2 Diabetes.
PG  - 2931985
LID - 10.1155/2016/2931985 [doi]
LID - 2931985
AB  - OBJECTIVE: We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) 
      and its clinical correlates in a population of patients with type 2 diabetes 
      mellitus (T2DM). METHODS: Clinical data of 94,577 T2DM patients were retrieved 
      from 160 diabetes clinics in Italy in a standardized format and centrally 
      analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol 
      intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the 
      diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were 
      evaluated through multivariate analysis. RESULTS: FLI-NAFLD was present in 59.6% 
      of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in 
      renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL 
      cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of 
      FLI-NAFLD patients (45.6% if the updated reference values were used). The 
      prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was 
      examined, irrespective of alcohol intake. CONCLUSIONS: FLI-NAFLD was present in 
      the majority of T2DM patients of our sample and metabolic derangement, not 
      alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients 
      have a worse metabolic profile. ALT levels are not predictive of NAFLD.
FAU - Forlani, Gabriele
AU  - Forlani G
AD  - Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" 
      University of Bologna, 40138 Bologna, Italy.
FAU - Giorda, Carlo
AU  - Giorda C
AD  - Diabetes and Metabolism Unit, ASL Turin 5, 10023 Chieri, Italy.
FAU - Manti, Roberta
AU  - Manti R
AD  - Diabetes and Metabolism Unit, ASL Turin 5, 10023 Chieri, Italy.
FAU - Mazzella, Natalia
AU  - Mazzella N
AD  - Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" 
      University of Bologna, 40138 Bologna, Italy.
FAU - De Cosmo, Salvatore
AU  - De Cosmo S
AD  - Unit of Internal Medicine, IRCCS Casa Sollievo della Sofferenza, 71013 San 
      Giovanni Rotondo, Italy.
FAU - Rossi, Maria Chiara
AU  - Rossi MC
AD  - Center for Outcomes Research and Clinical Epidemiology (CORE), 65124 Pescara, 
      Italy.
FAU - Nicolucci, Antonio
AU  - Nicolucci A
AD  - Center for Outcomes Research and Clinical Epidemiology (CORE), 65124 Pescara, 
      Italy.
FAU - Di Bartolo, Paolo
AU  - Di Bartolo P
AD  - Diabetes Unit, AUSL Romagna, 48121 Ravenna, Italy.
FAU - Ceriello, Antonio
AU  - Ceriello A
AD  - Biomedical Research Institute August Pi Sunyer (IDIBAPS) and Center for 
      Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), 
      08036 Barcelona, Spain.
FAU - Guida, Pietro
AU  - Guida P
AD  - AMD (Italian Association of Clinical Diabetologists), 00192 Rome, Italy.
CN  - AMD-Annals Study Group
AD  - AMD (Italian Association of Clinical Diabetologists), 00192 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160330
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*epidemiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Health Surveys
MH  - Humans
MH  - Italy/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Non-alcoholic Fatty Liver Disease/blood/diagnosis/*epidemiology
MH  - Odds Ratio
MH  - Prevalence
MH  - Prognosis
MH  - Risk Factors
PMC - PMC4829721
EDAT- 2016/04/29 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/03/30
CRDT- 2016/04/29 06:00
PHST- 2015/11/03 00:00 [received]
PHST- 2016/01/25 00:00 [revised]
PHST- 2016/02/29 00:00 [accepted]
PHST- 2016/04/29 06:00 [entrez]
PHST- 2016/04/29 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/03/30 00:00 [pmc-release]
AID - 10.1155/2016/2931985 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:2931985. doi: 10.1155/2016/2931985. Epub 2016 Mar 30.