PMID- 27124733
OWN - NLM
STAT- MEDLINE
DCOM- 20170324
LR  - 20190219
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 4
DP  - 2016
TI  - Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and 
      Associated Maternal and Fetal Morbidities in Pregnant Rats.
PG  - e0154405
LID - 10.1371/journal.pone.0154405 [doi]
LID - e0154405
AB  - Fetal growth restriction (FGR) and coagulopathies are often associated with 
      aberrant maternal inflammation. Moderate-intensity exercise during pregnancy has 
      been shown to increase utero-placental blood flow and to enhance fetal nutrition 
      as well as fetal and placental growth. Furthermore, exercise is known to reduce 
      inflammation. To evaluate the effect of moderate-intensity exercise on 
      inflammation associated with the development of maternal coagulopathies and FGR, 
      Wistar rats were subjected to an exercise regime before and during pregnancy. To 
      model inflammation-induced FGR, pregnant rats were administered daily 
      intraperitoneal injections of E. coli lipopolysaccharide (LPS) on gestational 
      days (GD) 13.5-16.5 and sacrificed at GD 17.5. Control rats were injected with 
      saline. Maternal hemostasis was assessed by thromboelastography. 
      Moderate-intensity exercise prevented LPS-mediated increases in white blood cell 
      counts measured on GD 17.5 and improved maternal hemostasis profiles. 
      Importantly, our data reveal that exercise prevented LPS-induced FGR. 
      Moderate-intensity exercise initiated before and maintained during pregnancy may 
      decrease the severity of maternal and perinatal complications associated with 
      abnormal maternal inflammation.
FAU - Kasawara, Karina T
AU  - Kasawara KT
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
AD  - Department of Obstetrics and Gynaecology, University of Campinas, Campinas, SP, 
      Brazil.
FAU - Cotechini, Tiziana
AU  - Cotechini T
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Macdonald-Goodfellow, Shannyn K
AU  - Macdonald-Goodfellow SK
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Surita, Fernanda G
AU  - Surita FG
AD  - Department of Obstetrics and Gynaecology, University of Campinas, Campinas, SP, 
      Brazil.
FAU - Pinto E Silva, Joao L
AU  - Pinto E Silva JL
AD  - Department of Obstetrics and Gynaecology, University of Campinas, Campinas, SP, 
      Brazil.
FAU - Tayade, Chandrakant
AU  - Tayade C
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Othman, Maha
AU  - Othman M
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Ozolins, Terence R S
AU  - Ozolins TR
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Graham, Charles H
AU  - Graham CH
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160428
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Blood Coagulation/drug effects
MH  - Female
MH  - Fetal Growth Retardation/chemically induced/physiopathology/*prevention & control
MH  - Fetus
MH  - Gestational Age
MH  - Inflammation/chemically induced/physiopathology/therapy
MH  - Leukocyte Count
MH  - Lipopolysaccharides/pharmacology
MH  - *Physical Conditioning, Animal
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Thrombelastography
PMC - PMC4849647
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/04/29 06:00
MHDA- 2017/03/25 06:00
PMCR- 2016/04/28
CRDT- 2016/04/29 06:00
PHST- 2015/12/31 00:00 [received]
PHST- 2016/04/13 00:00 [accepted]
PHST- 2016/04/29 06:00 [entrez]
PHST- 2016/04/29 06:00 [pubmed]
PHST- 2017/03/25 06:00 [medline]
PHST- 2016/04/28 00:00 [pmc-release]
AID - PONE-D-15-56554 [pii]
AID - 10.1371/journal.pone.0154405 [doi]
PST - epublish
SO  - PLoS One. 2016 Apr 28;11(4):e0154405. doi: 10.1371/journal.pone.0154405. 
      eCollection 2016.