PMID- 27124793
OWN - NLM
STAT- MEDLINE
DCOM- 20170918
LR  - 20240109
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Print)
IS  - 1935-1089 (Linking)
VI  - 11
IP  - 2
DP  - 2017 Spring
TI  - WALDENSTROM'S MACROGLOBULINEMIA MASQUERADING AS BIRDSHOT CHORIORETINOPATHY.
PG  - 152-155
LID - 10.1097/ICB.0000000000000316 [doi]
AB  - PURPOSE: To describe Waldenstrom's macroglobulinemia (WM) as a masquerade 
      syndrome. METHODS: Case report. RESULTS: A 59-year-old human leukocyte antigen 
      (HLA)-A29-negative white male presented with a 7-year history of floaters, 
      progressive vision loss, and poor contrast sensitivity along with choroidal 
      lesions suggestive of birdshot chorioretinopathy (BCR). Fluorescein angiography, 
      fundus autofluorescence, and indocyanine green angiography showed multiple areas 
      of hyperfluorescence and hypofluorescence. Electroretinography showed reduced 
      cone and rod responses. Comprehensive workup for infectious, paraneoplastic, and 
      other causes including sarcoidosis was negative at the time. The patient was 
      treated with multiple immunomodulatory agents without any significant 
      improvement. Two years after initial presentation, the patient developed 
      normocytic anemia and high levels of inflammatory markers. Further workup yielded 
      a diagnosis of WM. His choroidal lesions were significantly reduced after 
      treatment with rituximab and bendamustine. CONCLUSION: We report a case of WM 
      masquerading as BCR. Other indolent diseases should be considered in the 
      differential diagnosis for HLA-A29-negative patients presenting with 
      birdshot-like lesions, especially if they are clinically unresponsive to multiple 
      systemic immunosuppressive agents.
FAU - Kim, Jane S
AU  - Kim JS
AD  - *Laboratory of Immunology, National Eye Institute, National Institutes of Health, 
      Bethesda, MD; daggerMedical Research Scholars Program, National Institutes of Health, 
      Bethesda, MD; double daggerSchool of Medicine, University of California, San Diego, La Jolla, 
      CA;  section signIntramural Research Program, National Eye Institute, National Institutes of 
      Health, Bethesda, MD; and  paragraph signVirginia Cancer Specialists, Fairfax, VA.
FAU - Jaworski, Laurence
AU  - Jaworski L
FAU - Patel-Donnelly, Dipti
AU  - Patel-Donnelly D
FAU - Nussenblatt, Robert B
AU  - Nussenblatt RB
FAU - Sen, H Nida
AU  - Sen HN
LA  - eng
GR  - Z99 EY999999/Intramural NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
SB  - IM
EIN - Retin Cases Brief Rep. 2020 Summer;14(3):e3. PMID: 29621043
MH  - Birdshot Chorioretinopathy
MH  - Chorioretinitis/*diagnosis
MH  - Diagnosis, Differential
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Paraneoplastic Syndromes, Ocular/*diagnosis
MH  - Waldenstrom Macroglobulinemia/*diagnosis
PMC - PMC5083234
MID - NIHMS764808
COIS- Disclosures: The authors declare that they have no conflicts of interest to 
      disclose.
EDAT- 2016/04/29 06:00
MHDA- 2017/09/19 06:00
PMCR- 2018/04/01
CRDT- 2016/04/29 06:00
PHST- 2016/04/29 06:00 [pubmed]
PHST- 2017/09/19 06:00 [medline]
PHST- 2016/04/29 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 10.1097/ICB.0000000000000316 [doi]
PST - ppublish
SO  - Retin Cases Brief Rep. 2017 Spring;11(2):152-155. doi: 
      10.1097/ICB.0000000000000316.