PMID- 27125405
OWN - NLM
STAT- MEDLINE
DCOM- 20170425
LR  - 20170425
IS  - 1875-6263 (Electronic)
IS  - 1028-4559 (Linking)
VI  - 55
IP  - 2
DP  - 2016 Apr
TI  - Effects of a traditional Chinese medicine, Longdanxiegan formula granule, on 
      Toll-like receptor pathway in female guinea pigs with recurrent genital herpes.
PG  - 220-8
LID - S1028-4559(16)00032-2 [pii]
LID - 10.1016/j.tjog.2015.12.016 [doi]
AB  - OBJECTIVE: The aim of the present study was to investigate the effects of 
      Longdanxiegan formula granule (LDXGFG), a Chinese traditional medicine on 
      Toll-like receptor (TLR) pathway in recurrent genital herpes. MATERIALS AND 
      METHODS: An experimental recurrent genital herpes model was constructed using 
      herpes guinea pig model. The effect of LDXGFG on expression levels of TLR pathway 
      genes were detected using real-time polymerase chain reaction. Furthermore, the 
      dendritic cells and Langerhans cells were isolated and the TLR pathway genes of 
      these cells were assayed after LDXGFG treatment. RESULTS: The result suggested 
      two different expression patterns of TLR pathway genes in genital herpes and 
      recurrent genital herpes, including upregulated genes and downregulated genes. 
      TLR1, TLR4, TLR6, TLR7, TLR8, TLR9, and TLR10 showed a significant decrease 
      while, TLR2, TLR3, and TLR5 increased in genital herpes and recurrent genital 
      herpes guinea pigs. Meanwhile, the downregulated genes in genital herpes and 
      recurrent genital herpes were stimulated by LDXGFG. By contrast, the upregulated 
      genes decreased significantly after LDXGFG treatment. In both dendritic cells and 
      Langerhans cells, the TLR pathway genes exhibited same pattern: the LDXGFG 
      corrected the abnormal expression of TLR pathway genes. CONCLUSION: The present 
      results suggest that LDXGFG is an alternative, inexpensive, and lasting-effect 
      medicine for herpes simplex virus 2 infection.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Kuang, Lin
AU  - Kuang L
AD  - Hunan University of Chinese Medicine, Changsha, Hunan, China. Electronic address: 
      2235695017@qq.com.
FAU - Deng, Yihui
AU  - Deng Y
AD  - Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Liu, Xiaodan
AU  - Liu X
AD  - Hunan University of Chinese Medicine, Changsha, Hunan, China.
FAU - Zou, Zhixiang
AU  - Zou Z
AD  - The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 
      China.
FAU - Mi, Lan
AU  - Mi L
AD  - The Second Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 
      China.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Taiwan J Obstet Gynecol
JT  - Taiwanese journal of obstetrics & gynecology
JID - 101213819
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (longdanxiegan)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/drug effects/*metabolism
MH  - Disease Models, Animal
MH  - Down-Regulation/drug effects
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Gene Expression/*drug effects
MH  - Guinea Pigs
MH  - Herpes Genitalis/drug therapy/*genetics/metabolism
MH  - Langerhans Cells/drug effects/*metabolism
MH  - Recurrence
MH  - Signal Transduction/drug effects
MH  - Toll-Like Receptors/*genetics/*metabolism
MH  - Up-Regulation/drug effects
OTO - NOTNLM
OT  - Longdanxiegan formula granule
OT  - Toll-like receptor pathway genes
OT  - acyclovir
OT  - herpes simplex virus 2
OT  - recurrent genital herpes
EDAT- 2016/04/30 06:00
MHDA- 2017/04/26 06:00
CRDT- 2016/04/30 06:00
PHST- 2015/12/11 00:00 [accepted]
PHST- 2016/04/30 06:00 [entrez]
PHST- 2016/04/30 06:00 [pubmed]
PHST- 2017/04/26 06:00 [medline]
AID - S1028-4559(16)00032-2 [pii]
AID - 10.1016/j.tjog.2015.12.016 [doi]
PST - ppublish
SO  - Taiwan J Obstet Gynecol. 2016 Apr;55(2):220-8. doi: 10.1016/j.tjog.2015.12.016.