PMID- 27125772
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20220408
IS  - 0946-1965 (Print)
IS  - 0946-1965 (Linking)
VI  - 54
IP  - 8
DP  - 2016 Aug
TI  - Overuse of proton pump inhibitors for stress ulcer prophylaxis in Jordan.
PG  - 597-602
LID - 10.5414/CP202533 [doi]
AB  - OBJECTIVE: To determine the frequency of inappropriate proton pump inhibitor 
      (PPI) prescriptions during hospitalization for stress ulcer prophylaxis on the 
      general medical ward in a tertiary Jordanian hospital. MATERIALS AND METHODS: A 
      retrospective chart review was executed on 236 patient admissions prescribed any 
      PPI in a tertiary Jordanian hospital. For each patient, a detailed range of 
      demographic and clinical variables was recorded. Patient's clinical variables 
      were clustered into major vs. minor criteria for using PPIs in stress ulcer 
      prophylaxis according to the American society of health-system pharmacists' 
      (ASHP) therapeutic guidelines on stress ulcer prophylaxis. RESULTS: The 236 
      patients (51% females) had a mean age of 52 +/- 18.1 years. Approximately 56% of 
      the patients were using PPIs before admission. All our patients started PPI use 
      for stress ulcer prophylaxis. Of these, 86% were unnecessary and should be 
      avoided since they do not have at least 1 major or 2 minor indications. Previous 
      PPI use before admission or the presence of one risk factor for stress ulcer 
      motivated initiation of therapy predominately. Recent gastrointestinal (GI) 
      ulcer/bleeding (23%) and coagulopathy (8%) were the main major indications. 
      High-dose corticosteroid (24%) was the most frequent minor indication. 
      CONCLUSIONS: The high frequency of inappropriate PPI prescriptions in stress 
      ulcer prophylaxis for inpatients is a major issue in Jordan. Following the 
      current recommended therapeutic guidelines of stress ulcer prophylaxis could 
      minimize the overuse of PPIs in inpatient settings and thus decrease both the 
      possible safety issues of PPIs and the economic burden on the health-care system.
FAU - Alqudah, Mohammad A Y
AU  - Alqudah MA
FAU - Al-Azzam, Sayer
AU  - Al-Azzam S
FAU - Alzoubi, Karem
AU  - Alzoubi K
FAU - Alkhatatbeh, Mohammad
AU  - Alkhatatbeh M
FAU - Rawashdeh, Neda'
AU  - Rawashdeh N
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Int J Clin Pharmacol Ther
JT  - International journal of clinical pharmacology and therapeutics
JID - 9423309
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Inappropriate Prescribing
MH  - Jordan
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer/*prevention & control
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Stress, Psychological/*complications
EDAT- 2016/04/30 06:00
MHDA- 2017/01/28 06:00
CRDT- 2016/04/30 06:00
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/04/30 06:00 [entrez]
PHST- 2016/04/30 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 14363 [pii]
AID - 10.5414/CP202533 [doi]
PST - ppublish
SO  - Int J Clin Pharmacol Ther. 2016 Aug;54(8):597-602. doi: 10.5414/CP202533.