PMID- 27126954
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20170327
IS  - 1747-0803 (Electronic)
IS  - 1747-079X (Linking)
VI  - 11
IP  - 6
DP  - 2016 Dec
TI  - Long-term Outcomes after Truncus Arteriosus Repair: A Single-center Experience 
      for More than 40 Years.
PG  - 672-677
LID - 10.1111/chd.12359 [doi]
AB  - OBJECTIVES: This study aimed to analyze long-term survival and functional 
      outcomes after truncus arteriosus repair in a single institution with more than 
      40 years of follow-up. METHODS: Medical records were analyzed retrospectively in 
      52 patients who underwent the Rastelli procedure for truncus arteriosus repair 
      between 1974 and 2002. Thirty-five patients survived the initial repair. The 
      median age at the initial operation was 2.8 months (range, 0.1-123 months) and 
      the body weight was 3.9 kg (range, 1.6 to 15.0 kg). RESULTS: The median age at 
      follow-up was 23.6 years (range, 12.4 to 44.5 years). The median follow-up 
      duration was 23.4 years (range, 12.3 to 40.7 years). The actuarial survival rate 
      was 97% at 10 years and 93% at both 20 years and 40 years after the initial 
      operation. At follow-up, most patients were in New York Heart Association (NYHA) 
      functional classes I (73%) and II (24%). Thirty-six percent of patients had 
      full-time jobs, 40% were students, and 21% were unemployed. Most patients (97%) 
      had undergone conduit reoperations. Freedom from reoperation for right 
      ventricular (RV) outflow and pulmonary artery (PA) stenosis was 59% at 5 years, 
      28% at 10 years, and 3% at 20 years after the initial operation. Freedom from 
      catheter interventions for RV outflow and PA stenosis was 59% at 5 years, 47% at 
      10 years, and 38% at 20 years after the initial operation. Freedom from truncal 
      valve replacement was 88% at 5 years, 85% at 10 years, and 70% at 20 years after 
      the initial operation. CONCLUSIONS: In this single-center retrospective study, 
      with long-term follow-up after repair of truncus arteriosus, long-term survival 
      and functional outcomes were acceptable, despite the requirement for reoperation 
      and multiple catheter interventions for RV outflow and PA stenosis in almost all 
      patients, and the frequent requirement for late truncal valve operations.
CI  - (c) 2016 The Authors. Congenital Heart Disease published by Wiley Periodicals, Inc.
FAU - Asagai, Seiji
AU  - Asagai S
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Inai, Kei
AU  - Inai K
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Shinohara, Tokuko
AU  - Shinohara T
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Tomimatsu, Hirofumi
AU  - Tomimatsu H
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Ishii, Tetsuko
AU  - Ishii T
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Sugiyama, Hisashi
AU  - Sugiyama H
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Park, In-Sam
AU  - Park IS
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Nagashima, Mitsugi
AU  - Nagashima M
AD  - Department of Cardiovascular Surgery, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Nakanishi, Toshio
AU  - Nakanishi T
AD  - Department of Pediatric Cardiology, Heart Institute, Tokyo Women's Medical 
      University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160429
PL  - United States
TA  - Congenit Heart Dis
JT  - Congenital heart disease
JID - 101256510
SB  - IM
MH  - Activities of Daily Living
MH  - Adolescent
MH  - Adult
MH  - Arterial Occlusive Diseases/etiology/physiopathology/therapy
MH  - Cardiac Catheterization
MH  - Cardiac Surgical Procedures/*adverse effects/mortality
MH  - Child
MH  - Child, Preschool
MH  - Constriction, Pathologic
MH  - Disease-Free Survival
MH  - Female
MH  - Heart Defects, Congenital/diagnostic imaging/mortality/physiopathology/*surgery
MH  - Humans
MH  - Infant
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Pulmonary Artery/physiopathology
MH  - Reoperation
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Survivors
MH  - Time Factors
MH  - Tokyo
MH  - Treatment Outcome
MH  - Truncus Arteriosus/abnormalities/diagnostic imaging/physiopathology/*surgery
MH  - Vascular Patency
MH  - Ventricular Outflow Obstruction/etiology/physiopathology/therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Functional Outcome
OT  - Long-term Outcome
OT  - RV Outflow Stenosis
OT  - Truncal Valve Regurgitation
OT  - Truncus Arteriosus
EDAT- 2016/10/22 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/04/30 06:00
PHST- 2016/03/03 00:00 [accepted]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
PHST- 2016/04/30 06:00 [entrez]
AID - 10.1111/chd.12359 [doi]
PST - ppublish
SO  - Congenit Heart Dis. 2016 Dec;11(6):672-677. doi: 10.1111/chd.12359. Epub 2016 Apr 
      29.