PMID- 27127338
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20181113
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 80
IP  - 2
DP  - 2016 Apr
TI  - Comparison of 2 commercial single-dose Mycoplasma hyopneumoniae vaccines and 
      porcine reproductive and respiratory syndrome virus (PRRSV) vaccines on pigs 
      dually infected with M. hyopneumoniae and PRRSV.
PG  - 112-23
AB  - The objective of this study was to compare the efficacy of 2 different commercial 
      Mycoplasma hyopneumoniae vaccines and porcine reproductive and respiratory 
      syndrome virus (PRRSV) vaccines in regard to growth performance, microbiological 
      and immunological analyses, and pathological observation from wean to finish (175 
      d of age). Pigs were administered M. hyopneumoniae and PRRSV vaccines at 7 and 21 
      d of age, respectively, or both at 21 d old and then challenged with both M. 
      hyopneumoniae and PRRSV at 49 d old. Significant (P < 0.05) differences were 
      observed between the 2 vaccinated challenged groups in average daily weight gain, 
      nasal shedding of M. hyopneumoniae, M. hyopneumoniae-specific interferon-gamma 
      secreting cells, and macroscopic and microscopic lung lesions. Induction of 
      interleukin-10 following PRRSV vaccination does not interfere with the immune 
      responses induced by M. hyopneumoniae vaccine. The present study demonstrated 
      that the single-dose vaccination regimen for M. hyopneumoniae and PRRSV vaccine 
      is efficacious for controlling coinfection with M. hyopneumoniae and PRRSV based 
      on clinical, microbiological, immunological, and pathological evaluation.
FAU - Park, Changhoon
AU  - Park C
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Seo, Hwi Won
AU  - Seo HW
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Choi, Kyuhyung
AU  - Choi K
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Bacterial Vaccines)
RN  - 0 (DNA, Bacterial)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Bacterial Vaccines/*immunology
MH  - DNA, Bacterial/isolation & purification
MH  - Mycoplasma Infections/microbiology/prevention & control/*veterinary
MH  - Mycoplasma hyopneumoniae/*immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - RNA, Viral/isolation & purification
MH  - Swine
MH  - Viral Vaccines/*immunology
PMC - PMC4836037
EDAT- 2016/04/30 06:00
MHDA- 2017/03/16 06:00
PMCR- 2016/10/01
CRDT- 2016/04/30 06:00
PHST- 2016/04/30 06:00 [entrez]
PHST- 2016/04/30 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - cjvr_04_112 [pii]
PST - ppublish
SO  - Can J Vet Res. 2016 Apr;80(2):112-23.