PMID- 27128804
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20220129
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 130
IP  - 10
DP  - 2016 May 1
TI  - Smoke and viruses-a hindrance to relaxing the airways?
PG  - 839-41
LID - 10.1042/CS20160139 [doi]
AB  - Inhaled beta2-adrenoceptor agonists are a mainstay of therapy for airways diseases 
      and are almost universally prescribed for patients with asthma or chronic 
      obstructive pulmonary disease (COPD). Very few studies have evaluated the 
      efficacy of these commonly used therapies during acute disease exacerbations 
      which are frequently triggered by viral infection. In this edition of Clinical 
      Science, Donovan et al. assess the ex vivo effects of the most commonly used 
      short-acting beta2-agonist salbutamol on small airway reactivity using precision cut 
      lung slices (PCLS) from a mouse model of virus-induced exacerbation of COPD. They 
      demonstrate that combined challenge with cigarette smoke and influenza infection 
      in mice markedly impairs salbutamol-mediated airway relaxation. The findings of 
      the present study suggest that cigarette smoke and respiratory virus infection 
      may intefere with the ability of commonly prescribed therapies to effectively 
      bronchodilate the airways.
CI  - (c) 2016 The Author(s). Published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Singanayagam, Aran
AU  - Singanayagam A
AD  - Airway Disease Infection Section, National Heart and Lung Institute, Imperial 
      College, London W2 3PG, U.K.
FAU - Johnston, Sebastian L
AU  - Johnston SL
AD  - Airway Disease Infection Section, National Heart and Lung Institute, Imperial 
      College, London W2 3PG, U.K. s.johnston@imperial.ac.uk.
LA  - eng
GR  - G1000758/MRC_/Medical Research Council/United Kingdom
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Smoke)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
CON - Clin Sci (Lond). 2016 May 1;130(10 ):829-37. PMID: 27128803
MH  - Albuterol/therapeutic use
MH  - Animals
MH  - Asthma/drug therapy
MH  - Humans
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
MH  - *Smoke
MH  - Viruses
OTO - NOTNLM
OT  - chronic obstructive pulmonary disease
OT  - influenza
OT  - pharmacology
EDAT- 2016/04/30 06:00
MHDA- 2017/03/30 06:00
CRDT- 2016/04/30 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/03/29 00:00 [accepted]
PHST- 2016/04/30 06:00 [entrez]
PHST- 2016/04/30 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
AID - CS20160139 [pii]
AID - 10.1042/CS20160139 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2016 May 1;130(10):839-41. doi: 10.1042/CS20160139.