PMID- 27130618
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20220408
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 139
IP  - 6
DP  - 2016 Sep 15
TI  - Invasive Fusobacterium nucleatum may play a role in the carcinogenesis of 
      proximal colon cancer through the serrated neoplasia pathway.
PG  - 1318-26
LID - 10.1002/ijc.30168 [doi]
AB  - The prevalence of invasive Fusobacterium nucleatum (Fn) within the serrated 
      neoplasia pathway of the proximal colon has seldom been investigated. We examined 
      the invasive Fn and bacterial biofilms in 35 proximal hyperplastic polyps (HPs), 
      33 sessile serrated adenomas (SSAs), 48 proximal colorectal cancers (CRCs) and 10 
      matched metastatic lymph nodes using 16S rRNA fluorescence in situ hybridization 
      (FISH). Samples of normal mucosa, traditional adenomas (TAs), distal HPs, distal 
      CRCs and matched lymph nodes with or without metastases were used as controls. 
      The prevalence of invasive Fn within proximal HPs (65.7%) and SSAs (78.8%) were 
      significantly higher than that of proximal TAs (28.9%) and distal TAs (24.4%; 
      p < 0.05). Invasive Fn was detected in markedly more proximal CRCs (89.6%) than 
      in distal CRCs (42.2%; p < 0.05). Moreover, invasive Fn was detected in a 
      significantly higher proportion of matched metastatic lymph nodes (100%) than 
      that within nonmetastatic lymph nodes (40.0%; p < 0.001). Bacterial biofilms were 
      found on 52.1% of proximal CRCs, 55.6% of distal CRCs and 48.5% of SSAs. Biofilms 
      were positive for Fn in 47.9% of proximal CRCs, 48.9% of distal CRCs and 27.3% of 
      SSAs. However, the presence of Fn in biofilms was not related to invasive Fn 
      within colorectal tissues (p = 0.415). Invasive Fn may play a role in the 
      carcinogenesis of proximal colon developing via the serrated neoplasia pathway, 
      but might have a less important role in the TA-carcinoma sequence. Bacterial 
      biofilms may not contribute to the invasion of Fn into tumor tissues.
CI  - (c) 2016 UICC.
FAU - Yu, Jiahui
AU  - Yu J
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Chen, Yongyu
AU  - Chen Y
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Fu, Xiangsheng
AU  - Fu X
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Zhou, Xian
AU  - Zhou X
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Peng, Yan
AU  - Peng Y
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Chen, Ting
AU  - Chen T
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
FAU - Wu, Yaxin
AU  - Wu Y
AD  - Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical 
      College, Sichuan, China.
LA  - eng
PT  - Journal Article
DEP - 20160517
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cell Transformation, Neoplastic/metabolism
MH  - Colonic Neoplasms/diagnosis/epidemiology/*etiology/*metabolism
MH  - Female
MH  - Fusobacterium Infections/*complications/*microbiology/pathology
MH  - Fusobacterium nucleatum/pathogenicity/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - *Signal Transduction
OTO - NOTNLM
OT  - Fusobacterium nucleatum
OT  - biofilms
OT  - colorectal cancer
OT  - sessile serrated adenoma
EDAT- 2016/05/01 06:00
MHDA- 2017/04/30 06:00
CRDT- 2016/05/01 06:00
PHST- 2015/12/15 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/01 06:00 [entrez]
PHST- 2016/05/01 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
AID - 10.1002/ijc.30168 [doi]
PST - ppublish
SO  - Int J Cancer. 2016 Sep 15;139(6):1318-26. doi: 10.1002/ijc.30168. Epub 2016 May 
      17.