PMID- 27131093
OWN - NLM
STAT- MEDLINE
DCOM- 20170222
LR  - 20170816
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 145
DP  - 2016 Sep 1
TI  - Solid lipid microparticles for enhanced dermal delivery of tetracycline HCl.
PG  - 14-20
LID - S0927-7765(16)30291-0 [pii]
LID - 10.1016/j.colsurfb.2016.04.034 [doi]
AB  - Acne vulgaris (commonly called acne) is a most common skin disease during 
      adolescence, afflicting more than 85% of teenagers. Topical tetracycline (Tc) is 
      used for mild inflammatory acne and as an adjunct to systemic treatment in more 
      severe forms. Solid lipid microparticles (SLMs) are useful tool for topical 
      delivery because of their biodegradable, biocompatible and low toxic 
      characteristic accompanying with excellent skin hydration, occlusiveness and 
      controlled release properties. The purpose of this study was to prepare Tc-loaded 
      SLMs were produced by the spray drying technique and characterized by scanning 
      electron microscopy, powder X-ray diffractometry and differential scanning 
      calorimetry. In vitro and ex vivo release characteristics of Tc through SLMs and 
      control formulations (aqueous carbopol gel) were evaluated over 24h using a 
      vertical Franz diffusion cell through cellulose acetate membranes and exercised 
      rat skin, respectively. SLM formulations present high encapsulation values above 
      97% without significant different among formulations (p<0.05). The sustained 
      release pattern of Tc through SLMs was illustrated by in vitro release study. The 
      ex vivo drug skin permeation study revealed that Tc dermal deposition of optimum 
      SLMs formulation was about 7 times that of the control formulations. The enhanced 
      skin penetration and accumulation of Tc observed for Tc-loaded SLMs may increase 
      the efficiency of acne therapy and decrease the associated Tc side effects.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Rahimpour, Yahya
AU  - Rahimpour Y
AD  - Research Center for Pharmaceutical Nanotechnology and Student Research Committee, 
      Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Javadzadeh, Yousef
AU  - Javadzadeh Y
AD  - Biotechnology Research Center and Faculty of Pharmacy, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
FAU - Hamishehkar, Hamed
AU  - Hamishehkar H
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. Electronic address: hamishehkarh@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20160422
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Drug Carriers)
RN  - 0 (Lipids)
RN  - 0 (Tetracyclines)
SB  - IM
MH  - Administration, Cutaneous
MH  - Drug Carriers/chemistry
MH  - Lipids/*chemistry
MH  - Microscopy, Electron, Scanning
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Skin Absorption
MH  - Tetracyclines/*chemistry
OTO - NOTNLM
OT  - Acne
OT  - Dermal drug delivery
OT  - SLM
OT  - Skin
OT  - Solid lipid microparticle
OT  - Tetracycline
EDAT- 2016/05/01 06:00
MHDA- 2017/02/23 06:00
CRDT- 2016/05/01 06:00
PHST- 2015/12/16 00:00 [received]
PHST- 2016/04/15 00:00 [revised]
PHST- 2016/04/17 00:00 [accepted]
PHST- 2016/05/01 06:00 [entrez]
PHST- 2016/05/01 06:00 [pubmed]
PHST- 2017/02/23 06:00 [medline]
AID - S0927-7765(16)30291-0 [pii]
AID - 10.1016/j.colsurfb.2016.04.034 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2016 Sep 1;145:14-20. doi: 
      10.1016/j.colsurfb.2016.04.034. Epub 2016 Apr 22.