PMID- 27131150
OWN - NLM
STAT- MEDLINE
DCOM- 20170411
LR  - 20220330
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 125
DP  - 2016 Jun 5
TI  - Qualitative and quantitative analysis of chemical constituents of Centipeda 
      minima by HPLC-QTOF-MS & HPLC-DAD.
PG  - 400-7
LID - S0731-7085(16)30215-1 [pii]
LID - 10.1016/j.jpba.2016.04.029 [doi]
AB  - A high performance liquid chromatography coupled with quadrupole time-of-flight 
      mass spectrometry (HPLC-QTOF-MS) method in both positive and negative ion modes 
      was established to investigate the major constituents in the ethanolic extract of 
      Centipeda minima (EBSC). Twelve common components including flavones and their 
      glycosides, phenolic and polyphenolic acids, and sesquiterpene lactone were 
      identified in ten batches of samples based on comparison with the retention time 
      and accurate mass of external standards (mass accuracy within 3ppm) or the 
      fragmentation patterns of tandem MS. Meanwhile, a simple, accurate and reliable 
      HPLC-DAD method was also developed to determine the content of 10 chemical 
      markers simultaneously. Results obtained from method validations including 
      linearity, accuracy and precision showed that this new method is reliable and 
      robust. Isochlorogenic acid A and brevilin A were found to be the most abundant 
      in the ethanol extract of EBSC and could be served as markers for quality control 
      of EBSC.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Chan, Chi-On
AU  - Chan CO
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 
      China; Department of Applied Biology and Chemical Technology, The Hong Kong 
      Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
FAU - Jin, Deng-Ping
AU  - Jin DP
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 
      China.
FAU - Dong, Nai-Ping
AU  - Dong NP
AD  - Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic 
      University, Hung Hom, Kowloon, Hong Kong, China.
FAU - Chen, Si-Bao
AU  - Chen SB
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 
      China; Department of Applied Biology and Chemical Technology, The Hong Kong 
      Polytechnic University, Hung Hom, Kowloon, Hong Kong, China; Institute of 
      Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, China. Electronic address: sibao.chen@polyu.edu.hk.
FAU - Mok, Daniel Kam Wah
AU  - Mok DK
AD  - State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 
      China; Department of Applied Biology and Chemical Technology, The Hong Kong 
      Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address: 
      daniel.mok@polyu.edu.hk.
LA  - eng
PT  - Journal Article
DEP - 20160420
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
SB  - IM
MH  - Asteraceae/*chemistry
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Magnetic Resonance Spectroscopy/methods
MH  - Mass Spectrometry/*methods
MH  - Qualitative Research
OTO - NOTNLM
OT  - Brevilin A
OT  - Centipeda minima
OT  - Herbal analysis
OT  - Isochlorogenic acid A
OT  - Quadrupole time-of-flight mass spectrometry (QTOF MS)
OT  - Quality control
EDAT- 2016/05/01 06:00
MHDA- 2017/04/12 06:00
CRDT- 2016/05/01 06:00
PHST- 2016/01/11 00:00 [received]
PHST- 2016/04/16 00:00 [revised]
PHST- 2016/04/19 00:00 [accepted]
PHST- 2016/05/01 06:00 [entrez]
PHST- 2016/05/01 06:00 [pubmed]
PHST- 2017/04/12 06:00 [medline]
AID - S0731-7085(16)30215-1 [pii]
AID - 10.1016/j.jpba.2016.04.029 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2016 Jun 5;125:400-7. doi: 10.1016/j.jpba.2016.04.029. Epub 
      2016 Apr 20.